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Cochrane's 30 under 30: Ammar Sabouni

pon, 12/24/2018 - 11:34

Cochrane is made up of 13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.

Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all. 

Many of our contributors are young people working with Cochrane as researchers, citizen scientists, medical students, and volunteer language translators and we want to recognize the work of this generation of contributors as part of this series called, Cochrane’s “30 under 30." 

In this series, we will interview 30 young people, 30 years old or younger who are contributing to Cochrane activities in a range of ways, all promoting evidence-informed health decision making across the world. 

We will be hearing from them in a series of interviewees published over the coming months.

We're keen to hear from you. Would you like to take part in this series? Do you know someone you'd like to see interviewed? Contact kabbotts@cochrane.org.  Or if you want to know more about Cochrane’s work contact membership@cochrane.org where our community support team will be happy to answer your questions.

Name: Ammar Sabouni (on Twitter at @amosabo)
Age: 26
Occupation: Academic Clinical Trainee and Students 4 Best Evidence PioneerProgram: Academic Foundation Year 1 Doctor at Hull and East Yorkshire Hospitals NHS trust

How did you first hear about Cochrane?
I started medical school in Syria, a year before the start of the uprising. Towards the end of my first year I became interested in the activities of the Cochrane Schizophrenia group through one of my Psychiatry professors, Prof. Adib Essali. During my first two years at university I attended my first Cochrane Standard Author training in Damascus, by Prof. Clive Adams, head of the Cochrane Schizophrenia Group and I also had the chance to meet Sir Iain Chalmers and listen to his talk when he visited Damascus.

How did you become involved with Cochrane? What is your background?
Still in my basic science years at University studying to become a doctor I struggled to grasp the clinical contexts of the Cochrane reviews we were doing at first. Though my first systematic review was not a Cochrane one, later and with time I completed my first update of a Cochrane systematic review with the Cochrane Heart group. During this time, I became involved with Cochrane’s student initiative, Students 4 Best Evidence through which I was invited to come to Oxford for a placement within Cochrane UK.

What do you do in Cochrane?
I have since completed a number of consultancies for Cochrane UK including work on Cochrane review impact on Guidelines, early stages of the Cochrane-Wikipedia work, and Arabic translation work for Cochrane Bahrain, and become a Students 4 Best Evidence pioneer, authoring many blogs for the network. I have also continued to author Cochrane reviews for the Heart Group, Bone Muscle Joint Trauma group and am currently working on advancing Cochrane Arabic translation through a blogshot translation project.

What specifically do you enjoy about working for Cochrane and what have you learnt?
I know it may sound cheesy – but Cochrane is very much a huge family. Most people you will work with are there because they really believe in the work. I remember asking Sir Iain Chalmers if I could be involved in any research work while I was in Oxford and him telling me that in his opinion currently carrying out almost any primary research was unethical; that we should all be working on Cochrane systematic reviews, period. That is something you will really live and feel when working with people in Cochrane. It is a huge, multi-cultural, truly global collaboration of people who have come together because they really believe in the need for this work.



What are your future plans?
I received a bursary to attend the Global Evidence Summit in Cape Town but unfortunately was unable to attend because of the birth of my little baby girl, Maria. The ethos behind the Global Evidence Summit though I did not attend carries a lot of meaning for me. The fact that we need evidence-based policy not simply in health, in this day and age, is essential.

When many are keen to blur the lines between fact and fiction our best response is to produce, disseminate and advocate for the use of the best evidence and critical thinking for policy in all aspects of life. I am still searching for what truly interests me and where I can do the most good. Be that as it may rest my belief in the importance of the work that Cochrane does, best evidence and critical thinking, will go with me wherever I go.

In your personal experience, what one thing could Cochrane do better to improve its global profile?
I think there has been a lot of work to engage with much wider audiences. There is still much left for us to do to engage with younger generations. The nature of the work that Cochrane does makes this no easy task. I believe we can though create places where young authors work to create draft reviews and get instant feedback in a learning environment that is streamlined and friendly. In a way that will give people the opportunity to get stuck right into the work. In addition to helping with translations, dissemination and other tasks.

What do you hope for Cochrane for the future?
I hope Cochrane will continue to involve patient and wider communities into the synthesis and application of the amazing work that happens. I am ambitious that the evidence we produce we will keep finding new and innovative ways to translate directly into practice. I am especially excited about the Cochrane – Wikipedia work and hope that it will continue to bear fruit and help people get access to the best evidence.


How important is it that young people get involved in Cochrane? Why is this, do you think?
I think you may have gathered from above that I feel young people are essential for Cochrane. Context is key; with a collaboration of this magnitude and with how critical it is for the evidence we produce to be utilised. Eventually we will no longer understand the contexts that we work in as well as the younger generations. To make the work Cochrane does sustainable then we need to actively engage the younger generations.

What would your message be to other young people who want to get involved with Cochrane’s work but not sure where to start….?
With tens of thousands of volunteers from around the world Cochrane is a very large organisation. Start small and find any opportunity to help. Translations, task exchange, social media, and training courses are very good places to start. Students 4 Best Evidence are a great community and always welcome new people. It will take some time until you create your network of Cochranites but with a little perseverance you will find yourself a member of this big family. 

Remember that Cochrane produces one of the most rigorous methodological outputs in biomedical research. You will be able to play your part with some patience! Output will be well worth the wait. I attended Cochrane Colloquium Edinburgh and I met people I had not seen for years and it still felt like it was only yesterday!

Friday, February 15, 2019

Cochrane's 30 under 30: Emma Cartwright

pon, 12/24/2018 - 11:16

Cochrane is made up of 13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.

Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all. 

Many of our contributors are young people working with Cochrane as researchers, citizen scientists, medical students, and volunteer language translators and we want to recognize the work of this generation of contributors as part of this series called, Cochrane’s “30 under 30." 

In this series, we will interview 30 young people, 30 years old or younger who are contributing to Cochrane activities in a range of ways, all promoting evidence-informed health decision making across the world. 

We will be hearing from them in a series of interviewees published over the coming months.

We're keen to hear from you. Would you like to take part in this series? Do you know someone you'd like to see interviewed? Contact kabbotts@cochrane.org.  Or if you want to know more about Cochrane’s work contact membership@cochrane.org where our community support team will be happy to answer your questions.

Name: Emma Cartwright (on Twitter at @EmmaCartwrigh1)
Age: 29
Occupation: PhD student and Patient Editor
Program: Rosamund Snow Award

How did you first hear about Cochrane?
I first heard about Cochrane when I saw a Tweet about the colloquium in Edinburgh and how it was a patient included event which made me click on the link. It was then that I started to explore Cochrane and learn more about all of the work that happens at Cochrane.

How did you become involved with Cochrane? What is your background?
I became involved with Cochrane as the recipient of the Rosamund Snow Award. The award was for young health service users to attend the colloquium to find out more about Cochrane and how young people could become more involved in the work Cochrane does. My background is in Health Psychology, which I am currently studying a PhD in and I am also a person with Type 1 Diabetes, for which I do a lot of advocacy and peer support work. I am also a patient editor for the BMJ.

What do you do in Cochrane?
As part of the Rosamund Snow award I attended the colloquium in Edinburgh to learn about Cochrane and explore how patients could be further involved in the work Cochrane does. During the colloquium I, with the other prize winner, held a stand where we ask attendees of the colloquium (researchers, healthcare professionals and patients) how they had or hoped to involved patients in research. We collected the responses on a board so any attending the conference that wanted to involve patients more in their work could take some inspiration. I also supported the delivery of a workshop at the colloquium about how to involve patients in research with my colleagues from the BMJ. During this workshop we shared and explored how patients could sign up to become patient reviewers.

What specifically do you enjoy about working for Cochrane and what have you learnt?
My experience working with Cochrane so far has been very positive as I have found everyone to be very open to exploring new ways to better involve patients, and members of the public in research. I enjoy working with people from all over the world to bring together ideas and new ways of working which I think is a great strength of Cochrane being an international collaboration.

Since winning the Rosamund Snow award I have learnt who Cochrane are and what they do. Particularly around how they bring research studies together to create a review and how this can give more confidence when asking a question about health (e.g. is this medication effective). I have also learnt that researchers really want to help patients like me and how important it is for patients to be involved in research from the very beginning of research projects to ensure this happens.


What are your future plans?
Within the next few years, during my PhD, I hope to bring together my knowledge as a researcher in Health Psychology with being a patient to find new and better ways of involving young patients in research. I hope to be able to show researchers, and clinicians, the unique skills and knowledge that patients can bring to research projects. I also hope to empower patients to become more involved within the research process, ensuring their voices are heard when identifying areas of research, questions to be addressed, outcomes measured, research design and in the communication of findings. I would also like to continue working with Cochrane to explore how they can involve wider groups of patients (and the public) in the work they do and continue to involve patients in the colloquiums.

In your personal experience, what one thing could Cochrane do better to improve its global profile?
One thing I think Cochrane could do to better improve its global profile is to explore new ways of informing patients of its role and the information they can offer. I think Cochrane needs to become much more engaging, outside of the research community, by reaching out to groups who would not normally hear of Cochrane. In order to do this, I think Cochrane must work closely with clinicians who are seeing patients every day and can recommend Cochrane as a place for patients to find information about their condition. I would also suggest that Cochrane works with patient advocates or patient groups to also help share their work to the relevant patients and establish itself as the go to resource of information for patients.

I also think Cochrane needs to rethink its ways of communicating research to patients and the public. I personally find lay summaries difficult to engage with (e.g. lots of acronyms) and are still largely written in an academic format (e.g. number of studies included, number of participants). As a patient all I want to know is what does the evidence tell us and how does/could this affect me. You also have to know what a lay summary is and where to find it in order to engage with it which is not always easy. One way Cochrane could improve on this is through developing engaging videos, podcasts, short summaries (one paragraph) or infographics to communicate research findings in a much more accessible way. 

What do you hope for Cochrane for the future?
I hope that Cochrane continues to further patient involvement in research and that they involve patients in how best to carry this out. I think the colloquium in Edinburgh was a great step in really involving patients within the Cochrane community and attempting to try and involve different groups of patients (e.g. The Rosamund Snow award, Beyond the Room team with tweets and podcasts of the event). However, I would like to see patient involvement to continue to be a large focus of the colloquium by ensuring that patients are not only involved in the planning of the colloquium but also there at future events as well. I also hope that Cochrane takes on the feedback from patients to better improve patient involvement in events and research.
Finally, I hope that Cochrane can raise its profile as a credible, reliable and accessible resource for patients looking for information on their health.

How important is it that young people get involved in Cochrane?
I think it is incredibly important for young people to get involved in Cochrane as we can bring new, innovate and engaging ideas to shape the future direction.

Why is this, do you think?
Research and patient involvement are areas which are moving fast and constantly changing with many organisations trying to determine the best way to bring both of these together. Involving young people in Cochrane, especially patients, is important in ensuring that Cochrane’s direction is in line with the needs and wants of future contributors and users. Many organisations continue to do things because that is always how they have been. Sometimes a new, fresh pair of eyes looking at how things work and asking ‘why?’ can spark a change in moving things forward.

What would your message be to other young people who want to get involved with Cochrane’s work but not sure where to start….?
First of all I would say check out the Cochrane website. It is full of information and videos about what Cochrane is and what they do, from the very beginning including all of the basics is really helpful as a patient or young researcher. I would also say sign up to the Cochrane task exchange. You will be amazed at the number of skills you have that researchers are looking for and it is a great way to get involved with Cochrane with no or little prior knowledge of research.

Tuesday, February 12, 2019

Cochrane's 30 under 30: Robin Vernooij

pon, 12/24/2018 - 11:03

Cochrane is made up of 13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.

Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all. 

Many of our contributors are young people working with Cochrane as researchers, citizen scientists, medical students, and volunteer language translators and we want to recognize the work of this generation of contributors as part of this series called, Cochrane’s “30 under 30." 

In this series, we will interview 30 young people, 30 years old or younger who are contributing to Cochrane activities in a range of ways, all promoting evidence-informed health decision making across the world. 

We will be hearing from them in a series of interviewees published over the coming months.

We're keen to hear from you. Would you like to take part in this series? Do you know someone you'd like to see interviewed? Contact kabbotts@cochrane.org.  Or if you want to know more about Cochrane’s work contact membership@cochrane.org where our community support team will be happy to answer your questions.

Name: Robin Vernooij
Age: 29
Occupation: Post-doctoral researcher at the Netherlands Comprehensive Cancer Organisation and post-doctoral fellow at the Dalhousie University in the Nutritional Recommendations and Accessible Evidence Summaries Composed of Systematic Reviews (NutriRECS) group
Program: Netherlands Comprehensive Cancer Organisation

How did you first hear about Cochrane?
I became aware of Cochrane in 2011 while working on my Master's degree in Epidemiology and Biostatistics at the VU University in Amsterdam. One of my courses focused on the methodology and statistics of systematic reviews and meta-analyses. The Cochrane Handbook was a “suggested reading” and not surprisingly turned out to be an invaluable learning resource.

How did you become involved with Cochrane? What is your background?
My medical career started in 2006 at the HAN University of Applied Sciences in Nijmegen, the Netherlands where I obtained his Bachelor's degree in nursing in 2010. Afterwards, as part of my Master's degree, I completed a one-year placement at the Iberoamerican Cochrane Centre in Barcelona. Subsequently I was fortunate to continue to work at the centre for two more years. It was with the same centre, affiliated with Autonomous University of Barcelona, that I completed my PhD thesis in the Methodology of Biomedical Research and Public Health (2013 to 2018).

What do you do in Cochrane?
Apart from being employed by the Iberoamerican Cochrane Center for almost three years, I have been involved in the Cochrane community by collaborating with several Cochrane groups. In this capacity, I have helped author teams in completing their systematic reviews, including authors and editors of the Anaesthesia, Critical, and Emergency Care group; Dementia and Cognitive Improvement group; Urology group; and the Vascular group. Additionally, I serve as a contact editor for the Cochrane Urology group and as a regular peer-reviewer for the Cochrane Screening and Diagnostic Tests Methods Group.

What specifically do you enjoy about working for Cochrane and what have you learnt?
Working for Cochrane on a systematic review includes commonly a multidisciplinary collaboration between methodologists, statisticians, clinicians, and policy-makers. This collaboration allows me to learn more about the practices of the other involved disciplines. Secondly, I welcome any opportunity to learn more about the quality standards and emerging methods in conducting systematic reviews or meta-analyses. Being involved in the Cochrane collaboration allows me to remain up-to-date with the “gold standard” of systematic reviews and meta-analyses. Finally, contributing to the most comprehensive up-to-date evidence summaries on a given topic is very motivating.



What are your future plans?
Apart from my enthusiasm about systematic reviews, I am also keen on the development and updating of guidelines. Obviously, they go hand in hand since guidelines should be informed by the best summaries of the latest evidence available. My future plans are to collaborate on making an evidence ecosystem in which guidelines (informed by high-quality systematic reviews) are used to implement quality indicators in clinical practice. These quality indicators, based on the recommendations of the guidelines, should be used by healthcare professionals to treat their patients accordingly. Ideally, adherence to these quality indicators should be measured by registry data, allowing real-time feedback of the healthcare professionals performance.

In your personal experience, what one thing could Cochrane do better to improve its global profile?
Cochrane has grown a lot in the last five years and has many demands and priorities, particularly with respect to emerging methods including network-meta-analyses and living systematic reviews. I think that Cochrane should emphasise the need for living systematic reviews based on new practice-changing trials. If, at least, 75 new trials are published every day, it becomes very difficult to keep all available Cochrane reviews up-to-date. Methods and software development for identifying new trials, prioritising evidence that may be practice-changing, and conducting updates would be an asset to the organisation.

What do you hope for Cochrane for the future?
“It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials” (Cochrane 1979).

Although we have, over the last 40 years, came a long way, in my modest experience, there is still much room for improvement in the original aim. And now we are facing additional challenges, such as: how are we going to keep our systematic reviews and guidelines up-to-date? How do we prioritise practice-changing new evidence? And how do we use new technologies to facilitate systematic review development? I hope we can collectively work together to answer these questions.

How important is it that young people get involved in Cochrane?
As with most successful medical and public health organisations that are non-for-profit, research volunteers are crucial and it is important that a substantial proportion have healthcare and research training. It is important that trainees recognise the role of systematic reviews for evidence-informed health care decision-making. Crucial to learning about systematic reviews is the opportunity to have hands-on-experience.

Why is this, do you think?
For most of the young people, building both an academic and clinical network is crucial for the success of their career. Those pursuing a PhD project in the field of medicine or public health should consider –in my opinion – conducting or supporting a Cochrane review. This allows collecting all available evidence, understanding risk of bias issues, summarising the certainty of evidence to generate conclusions, and, identifying gaps in the current knowledge. The identified gaps could be used as inspiration on follow-up studies in a PhD project and beyond.

What would your message be to other young people who want to get involved with Cochrane’s work but not sure where to start….?
I would suggest reaching out to authors and editors that may be in need of a helping hand. For instance, Cochrane often posts on its website, reviews in need of update help, particularly priority reviews. Additionally, they can start browsing Cochrane’s TaskExchange for opportunities such as translation, data-extraction, or risk of bias assessment, as well as Cochrane Crowd, which allows gaining experience in literature screening. To get started, there are often simple tasks (e.g. literature screening, data-extraction) available on these websites that can be of great help to those leading the systematic review process, tasks that perhaps lead to co-authorship!

Tuesday, January 15, 2019

Cochrane's 30 under 30: Emma Persad

pon, 12/24/2018 - 10:25

Cochrane is made up of 13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.

Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all.

Many of our contributors are young people working with Cochrane as researchers, citizen scientists, medical students, and volunteer language translators and we want to recognize the work of this generation of contributors as part of this series called, Cochrane’s “30 under 30."

In this series, we will interview 30 young people, 30 years old or younger who are contributing to Cochrane activities in a range of ways, all promoting evidence-informed health decision making across the world.

We will be hearing from them in a series of interviewees published over the coming months.

We're keen to hear from you. Would you like to take part in this series? Do you know someone you'd like to see interviewed? Contact kabbotts@cochrane.org.  Or if you want to know more about Cochrane’s work contact membership@cochrane.org where our community support team will be happy to answer your questions.

Name: Emma Persad
Age: 26
Occupation: Part-time student researcher at the Department of Evidence-based Medicine and Clinical Epidemiology at Danube University Krems and Cochrane Austria
Program: Bachelor of Science Honours in Molecular Biology (Canada), Medicine (Austria)

How did you first hear about Cochrane?
Cochrane Austria is fortunately located on campus at the Department of Evidence-based Medicine and Clinical Epidemiology at Danube University Krems. Due to the convenience of having the Centre so close and the importance of teaching evidence-based medicine to medical students, Cochrane’s methods, work, and strict standards have been taught extensively since the first year of the program.

How did you become involved with Cochrane? What is your background?
My background is more in molecular biology and laboratory research, but after starting my medicine program I got introduced to Cochrane’s work and was lucky enough to get a job working alongside Cochrane Austria. I have always been passionate about public health and international affairs, so working for an international organization like Cochrane really fits my profile.

What do you do in Cochrane?
I’ve been involved in a variety of Cochrane reviews, with research and outreach for the Rapid Reviews Methods Group, and am currently leading an update of a Cochrane Review alongside my thesis.

What specifically do you enjoy about working for Cochrane and what have you learnt?
I really enjoy working for such a tight-knit community that is so determined to reach out with the best available evidence to both professionals and the general public. A great example of this is the plain language summaries of reviews to make the major points understood by lay people. As a future doctor, I have personally learned the importance of evidence-based medicine in my future career, and I can now appreciate that most people, especially doctors, don’t have time to read and synthesize all of the studies that are published. Thus, it is reassuring to have a set place to find the most trustworthy, all-inclusive, and up-to-date evidence.



What are your future plans?
I hope to work in the medical field while combing my passion for evidence-based medicine and public health into my career. I would like to stay involved in Cochrane’s work as much as possible and continue to be involved in reviews, when presented with the opportunity. I would eventually like to work with the WHO, and I’m sure my background with Cochrane will be a great asset for me there.

In your personal experience, what one thing could Cochrane do better to improve its global profile?
I think Cochrane could do a better job with student outreach and involvement. My university is lucky to have Cochrane so close and so involved in the curriculum, but I think many students in science and research-related disciplines unfortunately graduate without knowing what Cochrane even is. If Cochrane can be more present in universities, then people worldwide will know Cochrane’s work and take that knowledge into their careers with them. This could be made possible by country Centres offering internships to interested students or by holding lectures on Cochrane and how to get involved in relevant faculties at universities, for example.

What do you hope for Cochrane for the future?
I hope that the country Centres will continue to grow and expand so that Cochrane’s high-quality research can be done around the world and influence the public health and medical practices in each country. 

How important is it that young people get involved in Cochrane?
Very important!

Why is this, do you think?
I believe that youth involvement is needed to continue Cochrane’s work in the future and that people planning to work in this field should be exposed to Cochrane as early as possible. This way, proper recognition and respect for evidence-based medicine can be taught, passed-on, and used throughout their whole careers.

What would your message be to other young people who want to get involved with Cochrane’s work but not sure where to start….?
First of all, check out Cochrane’s website to find out the ways that you can get involved. Translating Cochrane reviews or becoming a Cochrane citizen scientist are good ways to start. You can also contact your country Cochrane Centre to see if you can do an internship or get involved in their work. 

Friday, January 4, 2019

Featured review: Uterotonic agents for preventing postpartum haemorrhage

čet, 12/20/2018 - 10:59

Which drug is best for reducing excessive blood loss after birth?

The aim of this Cochrane Review was to find out which drug is most effective in preventing excessive blood loss at childbirth and has the least side effects. The authors collected and analysed all the relevant studies to answer this question.

The review’s lead author Dr Ioannis Gallos from the University of Birmingham explains, “Bleeding after birth is the most common reason why mothers die in childbirth worldwide. Although most women will have moderate bleeding at birth, others may bleed excessively, and this can pose a serious risk to their health and life. To reduce excessive bleeding blood loss at childbirth, the routine administration of a drug to contract the uterus (uterotonic) has become standard practice across the world. The aim of this research was to identify which drug is most effective in preventing excessive bleeding after childbirth and has the least side-effects.

The different drugs oxytocin, misoprostol, ergometrine, carbetocin, and combinations of these drugs, each have different effectiveness and side-effects. Some of the side effects identified include: vomiting, high blood pressure and fever. We analysed all the available evidence to compare all of these drugs and calculated a ranking among them providing robust effectiveness and side-effect profiles for each drug.

We found all drugs were generally effective for preventing excessive bleeding when compared with no uterotonic drug treatment. Ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxytocin combination may have some additional benefits compared with the current standard oxytocin. The two combination drugs, however, are associated with significant side effects that women might find disturbing compared with oxytocin. Carbetocin may have some additional benefits compared with oxytocin and appears to be without an increase in side effects.”

This updated review includes 196 studies involving 135,559 women. Studies were conducted across 53 countries. In most studies women were giving birth normally and in a hospital.

Thursday, December 20, 2018

Interview with Dr Ioannis Gallos lead author of the updated Uterotonic agents for preventing postpartum haemorrhage: a network meta‐analysis

čet, 12/20/2018 - 10:47

The aim of this Cochrane Review was to find out which drug is most effective in preventing excessive blood loss at childbirth and has the least side effects. The authors collected and analysed all the relevant studies to answer this question.

The lead author of this review is Dr Ioannis Gallos. He is a Clinician Scientist in University of Birmingham and Honorary Consultant in Obstetrics & Gynaecology for Birmingham Women’s Hospital. Ioannis obtained his Degree in Medicine and Surgery (DMS) cum laude from the University of Rome, Italy. He subsequently trained in Obstetrics & Gynaecology in the UK and sub-specialised in Reproductive Medicine & Surgery before joining University of Birmingham.

Ioannis’ research is focussed on reproduction, early pregnancy and maternal health. Ioannis has carried out evidence synthesis including the first network meta-analysis in O&G within Cochrane with cost-effectiveness analysis for identifying the most effective and cost-effective uterotonic agents for preventing postpartum haemorrhage in collaboration with the World Health Organisation. He is the National Clinical Co-ordinator for the “Letrozole or Clomifene, with or without metformin, for ovulation induction in women with polycystic ovary syndrome: a 2x2 factorial design randomised trial (The LOCI trial)” funded by the NIHR HTA programme and is expected to roll out in 50 hospitals across the UK. Ioannis is a consultant for the Tommy's National Centre for Miscarriage Research based at Birmingham Women’s Hospital. He is also the principal investigator for Tommy’s Net, a platform that will help us to collect and store information from many different centres. By sharing information, hospitals will be able to work together to carry out more effective research.  

We asked the review’s lead author, Dr Ioannis Gallos  a few questions about this important Cochrane Review.

What is the history behind this updated review (what came before?)
This review was originally published in April 2018. It has been updated so soon to incorporate results from a large WHO trial and other recent large trials. We have added 56 new trials (46,612 women), and the update now includes a total of 196 trials (135,559 women). 

Why was it important to conduct this review?
The individual uterotonics described in the review have been compared in existing Cochrane Reviews and all comparisons are based on trials that directly compared one uterotonic against another uterotonic agent in head-to-head trials. In the absence of a single randomised controlled trial comparing all available uterotonic agents, uncertainty remains over their relative effectiveness and ranking. When multiple interventions are available, a network meta-analysis is better placed for synthesising and interpreting the wider picture of the evidence and to understand the relative effects of all available interventions. Network meta-analysis has advantages over conventional pairwise meta-analysis, as the technique uses both direct and indirect evidence in a single coherent analysis to improve certainty about all possible treatment comparisons. Indirect evidence is obtained when the relative effectiveness of two competing interventions is inferred through a common comparator, even though this pair may not have been compared directly. WHO wished to update their recommendations on prevention of postpartum haemorrhage for the first time using a Cochrane network meta-analysis.

Can you give a brief summary of results?
All agents were generally effective for preventing excessive bleeding when compared with no uterotonic drug treatment. Ergometrine plus oxytocin combination, carbetocin, and misoprostol plus oxytocin combination may have some additional benefits compared with the current standard oxytocin. The two combination drugs, however, are associated with significant side effects that women might find disturbing compared with oxytocin. Carbetocin may have some additional benefits compared with oxytocin and appears to be without an increase in side effects.

 How did you co-ordinate with WHO to have this review integrated into the guideline?
Together with Cochrane Pregnancy and Childbirth and WHO we ran, in parallel, the updated evidence synthesis for the effectiveness and safety of the uterotonic agents. Results of the synthesis were integrated to the guideline and presented to the WHO guideline development group as forthcoming evidence to help them reach a decision about which uterotonic to recommend.

What does the review mean in terms of influencing policy and/or practice?
The results of this work are already integrated in the recent WHO recommendations and we hope they are helpful to other policy-makers and practising clinicians. You can view this here.

 

Thursday, December 20, 2018

Featured Review: Interventions for treating wrist fractures (broken wrists) in children

sri, 12/19/2018 - 16:03

The recently published Cochrane Review from the Bone, Joint and Muscle Trauma Group assessed the best-quality evidence for different treatments of wrist fractures in children.

 Wrist fractures are the most common bone injury in children. Most are buckle (or torus) fractures, where the bone surface bulges out. These minor fractures heal well. They are often treated with a wrist splint or a below-elbow plaster cast.

More serious fractures are where the bone breaks, generally resulting in displacement of the bone parts. Usually the bone is manipulated back into place ('reduction'), followed by cast immobilisation, often with an above-elbow cast including the elbow. When considered, surgery generally involves placing wires through the skin and into the bone (percutaneous wiring).

The review includes 30 studies with 2930 children. Most of the 14 comparisons made by the studies were tested in one study only. The review focussed on five key comparisons. The three comparisons involving children with buckle fractures compared a removable splint with a below-elbow cast (6 studies); a soft or elasticated bandage with a below-elbow cast (4 studies); and cast removal at home by parents versus at the hospital fracture clinic by clinicians (2 studies). The other two comparisons, which involved children with displaced fractures, compared below-elbow versus above-elbow casts (4 studies) and percutaneous wiring and above-elbow cast immobilisation versus above-elbow cast immobilisation alone (5 studies).

Lead author Helen Handoll concluded, “There is not enough evidence to determine the best ways of treating different types of wrist fractures in children. However, the review findings are consistent with the treatment trend away from cast immobilisation for buckle fractures.”

 

Wednesday, December 19, 2018

Podcast: Lamotrigine versus carbamazepine monotherapy (single medication treatment) for epilepsy

uto, 12/18/2018 - 20:41

Up to 70 million people worldwide have epilepsy and there are many Cochrane Reviews of ways to treat it. These include reviews that work with the original researchers to gather data on everyone who was in their studies, to perform individual participant data meta-analyses. In June 2018, Sarah Nevitt and colleagues from the University of Liverpool in the UK updated one of these reviews, comparing two commonly used drugs, lamotrigine and carbamazepine.

"Carbamazepine and lamotrigine are both recommended as first-line treatments for people with newly diagnosed focal onset epileptic seizures and as second-line treatments for those with newly diagnosed generalised onset seizures, if first-line treatment with sodium valproate is considered unsuitable. Therefore, in order to help choose between them, we have brought together the evidence from randomised trials, increasing the precision of results relating to efficacy and tolerability of the two drugs. 

Our primary outcome for the analyses was the time between a patient starting the drug and being withdrawn from it, which reflects both how effective the drugs are for seizure control and the tolerability of the drugs in terms of side effects. We also examined secondary efficacy outcomes, including time to first seizure and remission of seizures, as well as the types and frequency of side effects. 

We found fourteen relevant trials for this updated review, involving nearly 3800 people, and were able to obtain individual participant data for more than 2500 people from nine of the trials, representing nearly 70 percent of all the data. 

Our main results from the meta-analyses of these data suggest that people are more likely to withdraw earlier from carbamazepine than from lamotrigine treatment, with the most common reason for withdrawal being side effects, followed by seizure recurrence. The results also suggest that recurrence of seizures after starting treatment with lamotrigine may happen earlier than with carbamazepine and that people will achieve a period of six months without a seizure quicker on carbamazepine than lamotrigine. Adverse events occurred with a similar frequency for both drugs. The most common ones were dizziness, fatigue, gastrointestinal disturbances, headache and skin problems.

In summary, the evidence from the randomised trials shows that both carbamazepine and lamotrigine are effective treatments for people with focal onset seizures. Carbamazepine may be superior in terms of seizure control, while lamotrigine therapy is less likely to be withdrawn than carbamazepine therapy. This means that a choice between these first-line treatments should be made with careful consideration, taking personal circumstances of individuals into account, and using the information in our updated review as a guide to what might happen to patients on either drug."

Tuesday, December 18, 2018

Cochrane Library Editorial: Treatment for Buruli ulcer

pon, 12/17/2018 - 19:02

Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans. It predominantly affects children below age 15 in sub‐Saharan Africa and people of any age in Australia. The infection manifests as a skin nodule, oedematous lesion, plaque, or ulcer. Transmission of Buruli ulcer is not entirely understood, with aquatic insects and mosquitoes being linked to disease transmission in some settings. It is clear, however, that disease is caused by the puncturing injury and introduction of the environmental pathogen into the skin and subcutaneous tissues. Whether the bacteria are thriving within a vector before they are transmitted (biological transmission) or merely transported and injected (mechanical transmission) is yet to be elucidated. Another hypothesis is that M ulcerans on the host skin is introduced following an insect bite or minor trauma.

A new Cochrane Infectious Diseases Review by included and discussed five randomized controlled trials and 13 prospective observational studies on drug treatment of Buruli ulcer - the first of its kind to formally assess the available evidence for drug treatment. This Cochrane Library Editorial discusses the latest findings, what we know, and what questions are still left unanswered.

Monday, December 17, 2018

Cochrane Crowd, Cochrane’s citizen science platform, breaks records in Mexico

pon, 12/17/2018 - 18:19

Cochrane Crowd, Cochrane’s citizen science platform, is a global community of volunteers who are helping to classify the research needed to support informed decision-making about health care.

The job of the Cochrane Crowd community is to review descriptions of research studies to identify and classify randomized controlled trials (RCTs), a type of study that is considered the gold standard for clinical trials. Reports of RCTs are then fed into Cochrane’s Central Register of Controlled Trials, helping Cochrane authors and other systematic reviewers around the world quickly find the evidence they need to determine whether a treatment works, or whether a diagnostic test is accurate.

A challenge held in partnership with the Cochrane Associated Centre at Sinaloa’s Pediatric Hospital (Mexico) and the Autonomous University of Sinaloa (Mexico) recently broke all previously held challenge records. 

Giordano Perez-Gaxiola, director of Cochrane Mexico and key challenge organiser said; "I had run a couple of small challenges through Cochrane Classmate with my students in the past year. I thought it was a simple way to motivate them to learn what Cochrane is, what a clinical trial is, and how an easy-to-use platform like Cochrane Crowd could help them learn. A couple of months ago I had a meeting with the dean of the medical faculty of the Autonomous University of Sinaloa (Universidad Autónoma de Sinaloa, UAS), Dr. Gerardo Alapizco, to discuss how the university and our Cochrane Associated Centre at Sinaloa’s Pediatric Hospital (Hospital Pediátrico de Sinaloa, HPS) could collaborate. I proposed setting up a university-wide challenge in order to engage a large number of students. This would introduce them to Cochrane and hopefully pique their interest, potentially leading to further engagement with Cochrane. This proposal was then discussed and approved by the medical faculty’s governing committee. We agreed that all students at UAS would be invited to take part."

Over three days from Dec 5-8, 738 people signed up, 455 participated and 319,643 individual assessments were made equating to 89,692 records being screened. 90 people screened at least 1000 records during the challenge and as a result were invited to become Cochrane members. And finally, almost 10,000 RCTs were identified for Cochrane’s CENTRAL register of controlled trials, where they can be accessed by systematic reviewers around the world.

Perez-Gaxiola added; "In my opinion, a Cochrane Crowd challenge is a simple way to engage students, to help them learn about Cochrane and about clinical trials. It is very easy to set up (takes about 10 minutes) and easy for the students to participate. It can be a useful teaching tool, too. And if you make it a competition, it can be fun."

Monday, December 17, 2018

Featured Review: Adverse events in people taking macrolide antibiotics versus placebo for any indication

pon, 12/17/2018 - 09:45

The review 'Adverse events in people taking macrolide antibiotics'  asked, “Will people taking a macrolide antibiotic experience more adverse events than those treated with placebo?”

Macrolide antibiotics are one of many types of antibiotic. They are commonly used to treat both acute and chronic infections. The four most commonly used macrolides are azithromycin, clarithromycin, erythromycin, and roxithromycin. People taking macrolide antibiotics are at risk of experiencing adverse events such as nausea, diarrhoea or rashes.

Lead author of the review Malene Plejdrup Hansen explains, “This review was undertaken to quantify adverse events in patients using macrolide antibiotics, independently of the indication or effects of the treatments. The intent is to support clinicians and patients in evaluating harms as well as benefits in the choice of management when antibiotics are considered.”

The review includes 183 studies with 252,886 participants. Most studies were conducted in hospitals. Azithromycin and erythromycin were more commonly studied than clarithromycin and roxithromycin. Most studies (89%) reported some adverse events or at least stated that no adverse events were observed. 

  • People treated with a macrolide antibiotic experienced gastrointestinal adverse events, such as nausea, vomiting, abdominal pain, and diarrhoea more often than those treated with placebo.
  • Taste disturbances were more often reported by people taking macrolides than those taking a placebo. However, very few studies reported on these adverse events, and results should be interpreted with caution.
  • Hearing loss was more often reported by people taking macrolide antibiotics; however, only four studies reported this outcome.
  • Macrolides caused less cough and less respiratory tract infections than placebo.
  • We did not find any evidence that macrolides caused more cardiac disorders, liver disorders, blood infections, skin and soft tissue infections, changes in liver enzymes, appetite loss, dizziness, headache, respiratory symptoms, itching, or rashes than placebo.
  • We did not find more deaths in people treated with macrolides than in those treated with placebo.
  • Very limited information was available to assess if people taking a macrolide antibiotic were at greater risk of developing resistant bacteria than those treated with placebo. However, bacteria that did not respond to macrolide antibiotics were more commonly identified immediately after treatment in people taking a macrolide than in those treated with placebo, but differences in resistance thereafter were inconsistent.

The quality of evidence ranged from very low (cardiac disorders, change in liver enzymes, liver disorders), to low (abdominal pain, death, diarrhoea, dizziness, hearing loss, skin and soft tissue infections, taste disturbance, wheeze), to moderate (appetite loss, blood infection, cough, fever, headache, itching, nausea, rash, respiratory symptoms, respiratory tract infections, vomiting) according to GRADE assessment.

 

Monday, January 21, 2019

Knowledge Translation in Cochrane Request for Proposal - Principles of Dissemination

pet, 12/14/2018 - 19:37

 Knowledge Translation in Cochrane is delighted to share this request for proposal for the project to agree a set of ‘principles for dissemination’ and to develop practical tools in order to improve the quality of Cochrane’s dissemination products.

This new and exciting opportunity is a commissioned piece of work open to the Cochrane community and will involve working with the Knowledge Translation (KT) ‘Improving and Upscaling KT products’ Working Group and our KT Advisory Group.

The deadline is Friday 18th January 2019, 17:00 GMT. For further information or any questions please contact Karen Head (khead@cochrane.org).

Friday, December 14, 2018

Cochrane Croatia celebrates its 10th birthday

pet, 12/14/2018 - 17:56

On Friday, 7th December, Cochrane enthusiasts gathered at the University of Split School of Medicine to celebrate the 10th anniversary of Cochrane Croatia.

Cochrane Croatia was founded as a Branch of the Italian Cochrane Centre on 8th December, 2008, ten years following initial discussions between Prof. Ana Marušić, Sir Iain Chalmers and Prof. Alessandro Liberati. Prof. Peter Tugwell, and his team, were instrumental in building capacity within Cochrane Croatia, along with the Mamić family who warmly welcomed several members of Cochrane Croatia into their family home, in Ottawa. Together, with the support of the Italian Cochrane Centre, later lead by Roberto D’Amico, Cochrane Croatia grew to become an independent Cochrane Centre in 2017. 

Today, Cochrane Croatia has 20 members, 19 partner organisations, 1 Affiliate - with another two in the pipeline. The Anniversary celebration was opened by the Vice-Dean for Research at the University of Split School of Medicine, Prof. Mirna Saraga-Babić, and by Cochrane Croatia’s Co-Director, Dr. Tina Poklepović Peričić. This was followed by an address given by the Chancellor of the University of Split, Prof. Dragan Ljutić and by Prof. Stipan Janković, Dean of the medical school in Split at the time Cochrane Croatia was founded. Prof. Ozren Polašek, Director of Croatian Centre for Global Health, underlined the importance of systematic reviews and Cochrane’s crucial role in their production and dissemination. Prof. Žarko Alfirević, from Cochrane Pregnancy and Childbirth, shared how Cochrane reviews influenced his clinical practice.  

The videos ‘Three patients and their stories contributing to Cochrane’s success’ and ‘Recognising success in Cochrane in 2017’ were screened. This was followed by Prof. Matko Marušić’s reminder of the early days of Cochrane Croatia, after which Cochrane Croatia’s Co-Director, Irena Zakarija-Grković, provided an overview of the first ten years, summarized in a published report ‘Cochrane Croatia: 2008-2018’. Finally, Dr Ljubo Znaor, Research Office Coordinator at the University Hospital Split, spoke of future projects with Cochrane Croatia.

All present celebrated Cochrane Croatia’s achievements with an appropriately decorated birthday cake and plenty of good cheer!

Irena Zakarija-Grković, Co-Director Cochrane Croatia

Friday, December 14, 2018

Cochrane launches Cochrane Czech Republic to support the use of high quality, trusted health information

sri, 12/12/2018 - 19:42

Cochrane, a global independent network of researchers, professionals, patients, carers and people interested in health, is proud to announce its newest Associate Centre,  Cochrane Czech Republic, at the Faculty of Medicine, Masaryk University, Brno.

Cochrane Czech Republic will promote evidence-based decision making in healthcare in the Czech Republic by supporting and training authors of Cochrane Reviews, as well as working with clinicians, professional associations, policy-makers, patients, and the media to encourage the dissemination and use of Cochrane evidence.

Cochrane works with collaborators from more than 130 countries to produce credible, accessible health information that is free from commercial sponsorship and other conflicts of interest.  Cochrane’s work is recognized as representing an international gold standard for high quality, trusted information.

Cochrane Czech Republic will be coordinated and led by its new Associate Director, Professor Dr. Miloslav Klugar: “The launch of Cochrane Czech Republic is very important. Producing and increasing the dissemination of the best available information on healthcare is critical for clinicians and patients everywhere in the world, including the Czech Republic. Cochrane Czech Republic is one of three important pillars of the Czech National Centre for Evidence-Based Healthcare and Knowledge Translation as an umbrella centre."

Cochrane’s Chief Executive Officer, Mark Wilson, warmly welcomed today’s news: “I am delighted we are announcing the launch of Cochrane Czech Republic, which I’m confident will deepen and expand the reach and impact of Cochrane activities on health and healthcare decision-making across the Czech Republic and therefore improve health outcomes for its 10.5 million citizens. This is why the establishment of Cochrane Czech Republic is so important. We hope that it will also promote health research in the Czech Republic
and Central European region and its application into policy and clinical practice across the country and the world.”

Jitka Klugarová, Associate Professor and Deputy Director for evidence syntheses and implementation, added: “This is an innovation for our region and we intend to collaborate in the dissemination of Cochrane Reviews and to continue supporting Cochrane to reach its 2020 strategic objectives.”

Andrea Pokorná, Associate Professor and Deputy Director for education activities also commented: “This is an excellent opportunity for scientific growth and gives us the chance to train students and a future generation of health workers that will develop high-quality research. Our chance to support health professionals in improving their decision-making based on the best available Cochrane evidence will support patient care.” 

Cochrane Czech Republic is an Associate Centre of Cochrane Germany. This means it will be supported by Cochrane Germany who will offer methodological support, mentoring, and supervision.

For more information on the work of the Cochrane Czech Republic, please visit the website: https://czechrepublic.cochrane.org

Facebook: @CochraneCzechRepublic

Twitter: @czcochrane

About Cochrane
Cochrane is a global independent network of researchers, professionals, patients, carers and people interested in health.

Cochrane produces reviews which study all of the best available evidence generated through research and make it easier to inform decisions about health. These are called systematic reviews.

Cochrane is a not-for profit organization with collaborators from more than 130 countries working together to produce credible, accessible health information that is free from commercial sponsorship and other conflicts of interest. Our work is recognized as representing an international gold standard for high quality, trusted information.

If you are a journalist or member of the press and wish to receive news alerts before their online publication or if you wish to arrange an interview with an author, please contact the Cochrane press office: pressoffice@cochrane.org

Wednesday, December 12, 2018

Cochrane seeks Cochrane US Network Coordinator - Flexible location within US

sri, 12/12/2018 - 15:25

Specifications: Part time 0.6 FTE, 1-year consultancy/secondment contract with potential to be extended
Salary: Competitive
Location: Flexible location within US
Application Closing Date: 19 January 2019

This role is an exciting opportunity to use your experience to make a difference in the field of health care research. 

The successful candidate will support the development of the Cochrane US Network. Working with a US-based Advisory Group and Cochrane’s Central Executive, the Cochrane US Network Coordinator will facilitate and support the Network’s establishment and development to deliver its strategic and operational objectives.

We are looking for a self-motivated and highly organised individual who is able to work effectively and collaboratively with a diverse range of contacts across the world.  The successful candidate will also have:

  • Master’s degree in communications; journalism; management; health sciences or a related discipline relevant to this position.
  • Experience in working in a networked setting.
  • Demonstrable experience in working with various partner organizations.
  • Understanding of the US research environment.
  • Experience in developing funding applications and engaging with funding agencies.
  • Ability to work independently under general direction, willing and able to work in a self-directed way.
  • Excellent interpersonal and communication skills, with a natural flair for networking.
  • Time management skills and ability to work flexible hours as needed.
  • Experience related to all aspects of the planning and organising of meetings, workshops and conferences.
  • Experience of working in an international context.
  • Willingness to travel nationally and internationally when required.
  • Be US based.

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information

If you would like to apply for this position, please send a CV along with a supporting statement to recruitment@cochrane.org with “Cochrane US Network Coordinator” in the subject line.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements for the post outlined in the job description using specific examples.  List your experience, achievements, knowledge, personal qualities, and skills which you feel are relevant to the post.

For further information, please see the full job description and the Cochrane US website.
Deadline for applications: 19 January 2019 (12 midnight GMT)
Interviews to be held on: (TBC)

Wednesday, December 12, 2018 Category: Jobs

Celebrating three-years of Cochrane Russia at the Cochrane Russia Symposium

uto, 12/11/2018 - 19:17

Cochrane Russia Symposium 2018, with the theme 'Cochrane Systematic Reviews as a key resource for health challenges in Knowledge Translation', was organized by the Research & Education Centre for Evidence-Based Medicine Cochrane Russia of the Kazan Federal University (KFU), Wiley ,and Nikolay Lobachevsky Scientific Library of KFU. It was held at the Kazan Federal University on December, 7, 2018.

The Symposium summed up Cochrane Russia activities for the three years of its existence, from the official start on December 7, 2015 at the International Conference "Evidence-Based Medicine: achievements and barriers" (QiQUM 2015), the major achievements and successes, plans for the future and the new promising projects.

Over 100 participants from all over Russia (Volgograd, Donetsk, Irkutsk, Kazan, Kaliningrad, Korolev, Moscow, Nizhnekamsk, Novosibirsk, Rostov-on-Don, St. Petersburg, Sochi, Tyumen, Ulyanovsk, Ufa) and other countries (Germany, Kazakhstan, Kyrgyzstan, Nigeria, the Netherlands, Uzbekistan, Ukraine) registered for the Symposium.

At the closure of the symposium, the organizers and participants provided feed-back on the event, identified areas for cooperation, plans and prospects for joint coordinated work.

A warm congratulations to Cochrane Russia for another successful Symposium!

 

Tuesday, December 11, 2018

Governing Board elections December 2018: Results

uto, 12/11/2018 - 15:52

Dear Cochrane Members,

Thank you for voting in the recent election for new members of the Cochrane Governing Board. Over 1200 people voted and over 4000 votes were cast.

We’re delighted to announce that the following four candidates have been elected:

Thank you to all the candidates who stood in this election, your contributions and willingness to serve Cochrane in this way are greatly appreciated. The full vote count is available on elections.cochrane.org. Learn more about the Governing Board on the Cochrane Community website. Questions about any aspects of the elections process can be raised with Lucie Binder, Senior Advisor to the CEO (Governance & Management) and Electoral Officer for this election.

Tuesday, December 11, 2018

Cochrane seeks Contracts Officer - London, UK

pon, 12/10/2018 - 21:27

Specifications: Full Time
Salary: up to £35,000 DOE
Location: London with flexibility to work from home up to 3 days a week
Application Closing Date: 2nd January 2019

This role is an exciting opportunity to use your experience as a Contracts Officer to make a difference in the field of health care research. 

The successful candidate will support the Senior Contracts Specialist in delivering an effective contracts management service to the Central Executive Team.

Key Tasks:

  • Manage and maintain a contracts database in conjunction with the Senior Contracts Specialist, including: record set-up and archiving; maintaining clean, searchable records through consistent use of naming conventions; establish thorough working knowledge of the database system and provide support to other internal users.
  • Prepare and issue (internally) monthly deadline reports for contracts due to end/be renewed/payments due.
  • Review final drafts of agreements, checking for key details (dates), errors and missing information.
  • Prepare spreadsheets collating information/metadata from contracts database on request.
  • Communicate with project leads (internal) and third parties to secure key contract details and signature.
  • Undertake responsibility for the execution of contracts, responding to any queries arising during the signature process and following-up on records awaiting signature to expedite execution.
  • Collate and record relevant information on Cochrane entities in the contracts database.
  • Assist the Office manager on an ad-hoc basis when required.

We are looking for a self-motivated and highly organised individual who is able to work effectively and collaboratively with a diverse range of contacts across the world.  The successful candidate will also have:

Essential

  • Degree in law or significant experience in contracts management
  • Previous experience of providing administrative support to a solicitor/contracts team
  • Excellent written and verbal communication skills
  • Experience of, or an interest in, learning about contracts drafting and negotiation in the research/healthcare sector
  • Experience of skim-reading contracts/reports
  • Previous demonstrable experience of database management
  • Ability to work methodically and accurately
  • Ability to work independently and use initiative/self-starter
  • A pro-active approach to problem-solving
  • Awareness of handling confidential and sensitive information
  • Intermediate level IT skills, including Word, Excel and PowerPoint
  • Strong organization and prioritization skills - a flexible approach with the ability to respond quickly to issues as they arise
  • Excellent interpersonal skills and ability to maintain a diplomatic, measured approach at all times.

Preferred:

  • Experience of contract drafting and negotiation
  • Experience of explaining complex issues and terms to non-experts clearly, accurately and concisely
  • Experience using online, cloud-based records management systems, such as Concord
  • Working in an international organisation

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information.

If you would like to apply for this position, please send a CV along with a supporting statement to recruitment@cochrane.org with “Contracts Officer” in the subject line.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements for the post outlined in the job description using specific examples.  List your experience, achievements, knowledge, personal qualities, and skills which you feel are relevant to the post.

For further information, please see the full job description.

Deadline for applications: 2nd January 2019 (12 midnight GMT)
Interviews to be held on: w/c 7th January 2019 (TBC)

Monday, December 10, 2018 Category: Jobs

Podcast: Electromechanical-assisted training for improving arm function and disability after stroke

pon, 12/10/2018 - 12:07

A common consequence for people who have a stroke is a reduction in their arm function. Various approaches are available to try to help and, in September 2018, the Cochrane Review for one of these, electromechanical and robot‐assisted arm training, was updated by a team of researchers from Germany. We asked lead author, Jan Mehrholz from Dresden Medical School, to tell us about the latest findings in this podcast.


"More than two‐thirds of people who have had a stroke have difficulties with reduced arm function. This can limit their ability to perform everyday activities and electromechanical and robot‐assisted arm training might help by using specialised machines to support shoulder, elbow and hand movements. Our review looks at the effects on arm function and muscle strength, and whether patients find it acceptable.

We identified 45 trials, involving a total of approximately 1600 participants; ranging from a trial with just eight participants to a US study with nearly 130. The trials assessed 24 different electromechanical devices, which were tested for between two and 12 weeks, and compared to a variety of other interventions.



Although the trials also used a variety of outcome measures, we can say that, on average, electromechanical and robot‐assisted arm training improves daily living for people after stroke, and improves the function and muscle strength of the affected arm. However, the effects were relatively small and might not be big enough to be seen as clinically important. Adverse events, such as injuries and pain, were seldom described, and so it does seem reasonable to include these devices in the rehabilitation of patients after a stroke but with some uncertainty about when and how often they should be used.

In summary, people who receive electromechanical and robot‐assisted arm training after a stroke might improve their activities of daily living, arm function, and arm muscle strength. However, although the quality of the evidence was high, we still need to be cautious because the benefits are small and there were substantial differences between the trials in the intensity, duration, and amount of training; and the types of treatment, participants and outcomes measurements used."

Wednesday, January 30, 2019

Podcast: Omega-3 fatty acid addition during pregnancy

sub, 12/08/2018 - 10:31

Omega-3 fats are the subject of more than two dozen Cochrane Reviews for conditions including cardiovascular health, dementia and gastrointestinal problems. In November 2018, the review on the effects on preterm birth when these are taken by pregnant women was updated. The review was led by Associate Professor Philippa Middleton and Professor Maria Makrides, from the Healthy Mothers Babies and Children theme at the South Australian Health and Medical Research Institute. Professor Makrides tells us about the latest evidence.


"In Australia, about 1 in 12 babies are born prematurely, this means that they are born more than three weeks before the usual 40 weeks of pregnancy. This is a problem because premature birth is responsible for around 85% of all health complications in early life and is the leading cause of death in children under 5.

There are very few strategies to prevent women from going into early labour and delivering a premature baby. However, one of the things that our research team has been studying is whether the omega-3 long-chain fatty acids, such as DHA and EPA that are found in fish and fish oils, can extend the length of pregnancy.

We have now completed our Cochrane systematic review that brings together all the published randomised trials that test the effects of these long chain omega-3 fats during pregnancy on the health of mothers and their babies. We included 70 studies, which contained more than 19,000 women in the trials. The review shows that there is high-quality evidence that supplementation with long-chain omega-3 fats during pregnancy, particularly with DHA, reduced the risk of having a premature baby by 11% and it also reduced the risk of having a very premature baby, born before 34 weeks, by 42%.

Based on these findings, we suggest that pregnant women with one baby take between 500 and 1000mg of long-chain omega-3s every day from the 12th week of pregnancy. It’s best if these supplements contain at least 500mg of DHA per day. As a result of the review, we are revising clinical practice guidelines for health professionals who are working in pregnancy care to try and encourage pregnant women to supplement their diets with omega-3s, to increase their chances of having a healthy full-length pregnancy."

Wednesday, December 12, 2018

Stranice