Cochrane London 2023: Forward together for trusted evidence
4-6 September 2023
Central London, UK

Cochrane UK is delighted to be hosting the  Cochrane Colloquium at the Queen Elizabeth II (QEII) Centre in London, UK from the 4 to 6 of September 2023, with satellite events and meetings on the 3rd September.

Cochrane holds an annual conference, known as a Colloquium, that brings together Cochrane researchers, clinical professionals, early career professionals, patients and carers, policymakers, and anyone interested in evidence synthesis and evidence-based healthcare. The events are a mix of keynote speakers, training opportunities, workshops, presentations, and a lively social and networking atmosphere. They are an exciting opportunity for a community of evidence synthesis enthusiasts to share, learn, and connect.  

The deadline for submissions has been extended until Monday 6 March 2023 (23:59 GMT)

The theme of the Colloquium is 'Forward together for trusted evidence', which explores the challenges for the future around the trustworthiness of healthcare information whilst also celebrating 30 years of producing trusted evidence. 

We invite abstract submissions for the following streams: producing trusted evidence; advocating for trusted evidence; informing health and care decisions; and co-production and working together. 

We recognize that everything Cochrane does is about and for patients and other health consumers. We ask that all abstract submissions consider the impact on patients and healthcare consumers. In particular, we welcome submissions that are co-produced, co-presented or co-designed with patients or other healthcare consumers.

If you are planning to submit an abstract, please see our guidance and recommendations:

• Abstract submission guidance (for posters and oral presentations)
• Workshop submission guidance 

 Catherine Spencer, Cochrane CEO said, “The Cochrane Colloquium will bring people together in one place to discuss, develop and promote Cochrane’s work. I am looking forward to a packed programme at my first Colloquium and encourage you to submit your contributions now.”

Martin Burton, Director of Cochrane UK, said: “We look forward to receiving your abstract submissions for London 2023. You can now submit abstracts for posters, oral presentations, or workshops – and we have guidance to help you.” 

We invite everyone to visit the Colloquium website for all information related to the Colloquium as it's released, including submissions for abstracts and awards/prizes, registration, stipend applications, and the event programme.

• Abstract submission guidance
• Workshop submission guidance 
• Colloquium website 
• #CochraneLondon
• Press contact: Katie Abbotts, Cochrane UK

 

Wednesday, March 1, 2023

Lijekovi za sprječavanje ugrušaka nakon krvarenja u mozgu Istraživačko pitanje Koje su dobrobiti i rizici lijekova koji se koriste za sprječavanje stvaranja ugrušaka (poznatih kao 'antitrombotici') kratkoročno i dugoročno nakon moždanog udara zbog krvarenja u mozgu (poznato kao 'moždano krvarenje')? Dosadašnje spoznaje Ljudi s moždanim udarom zbog krvarenja u mozgu imaju veću vjerojatnost za razvijanje ugrušaka u krvnim žilama nego ljudi bez krvarenja u mozgu. Nepokretnost rano nakon moždanog udara može uzrokovati ugruške u venama nogu i zdjelice. Osnovna medicinska stanja pacijenata,...

Jesu li koncentrirana protutijela od ljudi ili životinja koji su se oporavili od COVID-19 učinkovit oblik liječenja za pacijente s bolešću COVID-19? Ključne poruke • Ne znamo smanjuje li hiperimuni imunoglobulin (pripravak napravljen s protutijelima ljudi koji su preboljeli COVID-19) smrtnost ili ozbiljne neželjene učinke kod ljudi s umjerenim do teškim oblikom COVID-19. Sličan pripravak napravljen ubrizgavanjem određenih protutijela životinjama može smanjiti smrtnost i ozbiljne neželjene učinke te može spriječiti pogoršanje stanja. • Nismo pronašli nijedno ispitivanje koje je istraživalo...

Title: Head of Fundraising
Specifications: Permanent – Full Time
Salary: £60K per annum
Location: Ideally based in the UK, Germany or Denmark. Candidates from the rest of the world will be considered; however, Cochrane’s Central Executive Team is only able to offer consultancy contracts outside these countries (1-year fixed-term contracts)
Directorate: Development
Closing date: 21 Feb, 2023

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters from more than 220 countries. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into five directorates: Evidence Production and Methods, Publishing and Technology, Development, and Finance and Corporate Services.

The Head of Fundraising will lead a small and dedicated team to provide the necessary vision, leadership, and fundraising skills which will enable the organisation to achieve its fundraising targets and organisational Development Strategy. They will have substantial international fundraising and management experience, a talent for building relationships and a proven track record in securing funds from international institutions, statutory sources, major international trusts and foundations, and major donors.

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organization is built on four core values: Collaboration: Underpins everything we do, locally and globally. Relevant: The right evidence at the right time in the right format. Integrity: Independent and transparent. Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

• An opportunity to truly impact health globally
• A flexible work environment
• A comprehensive onboarding experiences
• An environment where people feel welcome, heard, and included, regardless of their differences

Cochrane welcomes applications from a wide range of perspectives, experiences, locations and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

• For further information on the role and how to apply, please click here.
• The deadline to receive your application is 21st Feb, 2023.
• The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
• Read our Recruitment Privacy Statement

Wednesday, January 25, 2023 Category: Jobs

Intervencije za poboljšanje sanitarnih uvjeta u cilju sprječavanja proljeva Cilj Cochraneovog sustavnog pregleda Cilj ovog Cochraneovog sustavnog pregleda bio je procijeniti mogu li sanitarne intervencije smanjiti učestalost proljevastih stolica, kako bi se omogućili i unaprijedili zahodi ili latrine ili potaknuli ljudi da ih koriste. Prikupili smo i analizirali sva relevantna istraživanja unaprijed određenog dizajna i pronašli 51 istraživanje koje je ukupno uključilo 238,535 ljudi. Ključne poruke Pronašli smo dokaze da sanitarne intervencije mogu zaštititi od proljeva. Međutim, učinci su se...

Cochrane is delighted to announce the availability of RevMan Web, its popular, web-based systematic-review production software, to the wider academic community beyond Cochrane – to support evidence synthesis development and evidence-based medicine education. Cochrane expects interest in use of the tool from those in universities and medical schools, and many other research sectors.

RevMan Web facilitates the creation of meta-analyses, forest plots, risk-of-bias tables, and other systematic review elements. It is acknowledged to be easy-to-use – and is also widely used in learning or training about systematic review production.

Cochrane is making RevMan Web available for use by institutions or individuals for their own systematic review development work. The product is presented on a Software-as-a-Service basis: Cochrane offers a hosted service, comprising the software and cloud storage of all review data uploaded. 

Laura Ingle, Cochrane’s Director of Publishing and Technology, says this is a hugely positive step forward: “Cochrane’s investment and development of RevMan Web has allowed the preparing and maintaining of Cochrane Reviews to reach our high standards and methodologies – making Cochrane reviews the gold standard in health evidence. Cochrane is committed to making RevMan Web the platform of choice for all systematic review production, and now we are enabling access to RevMan Web for the wider review community at a reasonable and affordable cost.

"In addition to reviews of studies of the effects of healthcare interventions, you can use RevMan Web to write reviews that synthesize qualitative evidence, reviews of prognosis studies, reviews of studies of methodology, diagnostic test accuracy reviews, and overviews of reviews. RevMan Web is easy to use, is a safe and central place to manage all reviews, and allows collaboration across people to work on the same project. With its included learning and training materials, it also makes it a great training tool for teaching systematic review techniques. 

"Cochrane authors have been using RevMan for 5 years and we are excited to offer this systematic review and meta-analysis software to individual researchers, those working on reviews together, and to those looking for licences for their university. It’s a great tool for those generating one-off meta-analyses and forest plots or conducting their own systematic reviews.”

Free access is available in Research4Life low and middle-income countries and to Cochrane Review authors working on Cochrane Reviews. Cochrane authors working on non-Cochrane reviews, Cochrane Members, students,  and academics are eligible for a discounted rate. 

To find out more:

• Visit the RevMan Web website
•  RMWsubscriptions@cochrane.org

Friday, March 24, 2023

Tuesday, January 24, 2023

Dr Jenny McSharry, Health Psychologist and lecturer in the School of Psychology at the University of Galway, explains what systematic reviews are and why they are a particularly trustworthy source of health evidence. 

Dr Jenny Mc Sharry was supported by an Evidence Synthesis Ireland Writing Mentorship (Grant code ESI-2021-001) and this blog post was originally posted on Evidently Cochrane.

When we are diagnosed with a new condition, experience a worrying symptom or need to make a health decision for ourselves or our loved ones, it can be hard to know where to turn. How often have we found ourselves unable to sleep, alone at 3AM, searching online for answers to questions we never thought we would have to ask?  In times of anxiety and uncertainty, how can we know what health evidence to trust when we need it most?

When looking for reliable information to help with health decisions, reviews of evidence, in particular systematic reviews, can be a good place to start.

Systematic reviews of multiple studies can be useful for health decisions

Reviews that bring together and summarise the existing evidence are more reliable than one research study, or one person’s opinion or experience. Lots of things can affect the findings of a research study and we can have more confidence in reviews that bring together lots of studies. There is more information on why Personal experiences or anecdotes (stories) are an unreliable basis for assessing the effects of most treatments on the Evidently Cochrane blog.

Systematic reviews are seen as the gold-standard of research evidence. A systematic review is a type of review that tries to find, assess, and summarise all the evidence that meets pre-specified criteria to answer a specific question. Researchers who complete systematic reviews follow a number of key steps to make their findings more trustworthy.

Systematic reviews summarise evidence related to a specific question

Systematic reviews look for evidence that might help answer a specific question, and clearly outline this question from the start. For example, a systematic review Antihistamines for motion sickness was done to find out if  medicines used for allergy symptoms (antihistamines) work and are safe in preventing travel (motion) sickness. The review summarises evidence on how antihistamines compare with dummy treatment (placebo), no treatment, and other medicines. This review is useful if you want to find evidence about medicines for travel sickness, but not if you want to know if you should avoid reading or drink ginger tea while travelling. When a review clearly states its focus, it helps us judge whether it is relevant and useful to us.

Systematic reviews aim to find all studies that meet certain criteria

Systematic reviews researchers try to find and include all studies relevant to a specific question. This is important, as we want all relevant information to be available to us when making a health decision. When using evidence from a review to decide if we should start a new treatment for example, we want to be sure that studies that found benefits, studies that found harms, and studies that found little or no difference, are just as likely to have been included.

Systematic review researchers try to find all relevant studies by clearly outlining the sources they will search, and by making a list of the criteria they will use to decide if studies should be included. For example, in our review Video calls for reducing social isolation and loneliness in older people, we wanted to find out if older people who used video calls to keep in touch with family and friends feel less lonely than those who did not. For this review, we needed to decide on what we meant by older adults, as the findings might be different for people aged 65 and older, or people aged 70 and older. For this review, we decided to include studies of people aged 65 and older and made it clear when reporting the findings that this was the group we had focused on.

Systematic review researchers clearly state the methods they will use to identify studies before starting the review. Other researchers should be able to use these methods and find the same set of studies.

Systematic reviews assess and report on the quality of evidence

When reading reviews of evidence, it is important to know how many relevant studies there are, but also to know if the studies are of good quality. Even if a number of studies find that a treatment is beneficial, we may not want to choose this treatment if we find out that the number of people included in the studies was very small, or that the way in which people were identified to take part in the studies was not clear. For a systematic review, researchers assess if the methods used in the included studies were appropriate. Researchers then make a judgement on the level of certainty we can have in the overall evidence, based on whether the included studies were done well or not.

Finding relevant systematic reviews: Where to look?

When it comes to trustworthiness, not all information we find is equal, and it is good to know that systematic reviews can be helpful in making health decisions. However, when feeling anxious about a health condition or symptom, or when trying to make an urgent health decision, it can be hard to know how to find relevant systematic reviews.

Cochrane is an independent global organisation that aims to provide high-quality evidence to inform decisions about health and care. Cochrane systematic reviews are published online in the Cochrane Library. The Cochrane Library is free to access for people in the UK and Ireland (and in many other countries). You can search by topic, and the reviews all have a Plain Language Summary. The blogs here on Evidently Cochrane aim to make health evidence easy to understand and use by providing summaries of Cochrane Reviews in context, often alongside patients’ and health professionals’ experiences. Evidently Cochrane includes an A-Z list of topics to make it easier to search for relevant evidence, and can be a good place to start when supporting family and friends or making choices about our own health.

What else can you do to work out if health information is trustworthy?

If you are interested in finding out more about health information and what we can trust, the blog, Making health decisions: things that can help, looks at some key things to consider to help us to make the right decision and to reduce the risk of regretting our choices later on. The blog also reminds us that summaries of research evidence are just one part of how we make health decisions, and our own preferences and values and the views of healthcare professionals are also very important. The blog includes lots of resources to help you think critically about health information and to support your decision-making.

• Learn more about health evidence in our free Cochrane Evidence Essentials resource
• Read more Evidently Cochrane blogs
• Join in on the conversation on Twitter with @jenmcsharry @CochraneUK or leave a comment on the blog

Tuesday, January 24, 2023

Monday, January 23, 2023

Friday, January 20, 2023

Friday, January 20, 2023

Family-centred care is a way of providing care that focuses on the needs of children while providing planned care around the whole family unit. A new Cochrane review published recently found there was a small improvement in the overall health and well-being of Indigenous children and their families when they participated in family-centred care programmes at a primary healthcare service.

‘Family centred-care is not new,’ says lead author Dr Natalie Strobel, Senior Research Fellow at Edith Cowan University’s Centre for Improving Health Services for Aboriginal and Torres Strait Islander Children and Families. ‘Aboriginal Medical Services have been doing this for years. For example, they don’t just immunise babies, they talk to mums, aunts, uncles, grandparents and everybody that’s part of that family unit – trying to ensure that everybody's getting care. That’s both health and social care, so it might be making sure there’s appropriate housing, referrals to services that they needed or for other types of support.’

‘We know that primary healthcare, particularly Indigenous-led services, are well placed to deliver services that reflect the needs of Indigenous children and their families. Of our author team of nine, four are Aboriginal and have worked in health services as nurses and midwives for a long time. Families want primary healthcare services that both support them and recognise Indigenous ways of knowing and doing business. This can be delivered through environmental, communication, educational, counselling, and family support approaches.’

A key finding of this new review was that family-centred care delivered by primary healthcare services may improve the overall health and well-being of children and their families, however, due to a range of factors, the evidence was rated as very low certainty. There was also evidence to suggest that families who participated in family-centred care increased their parenting knowledge and awareness to a small degree. However, for all other outcomes it was unclear whether family-centred care improves specific child health and well-being outcomes. Ultimately more high quality trials are needed to generate evidence to determine whether family-centred care improves the health and well-being of Indigenous children.

‘We consider family-centred care to be really promising, but we’re not confident in the evidence for a range of reasons, which are quite complex,’ Natalie says. ‘For example, people in the studies were aware of what intervention they were getting, many people did not come back to report their results, and not all the studies reported the information we were interested in. Also, some of the issues around low quality of evidence are really hard for communities that are doing this type of work to get around.’

‘For instance, in the United States you're delivering the intervention on a reservation and there's not a huge number of people to do this work. Often the person who delivers the intervention also collects the data. We know that's got a significant level of bias involved in it, but it's also very pragmatic, that's what happens and how it has to work because there's not enough people to complete the project. This highlights the challenges of conducting high quality studies, and underscores the need to build capacity and support people in communities.’

‘I think with the advent of this type of research, it will give people an idea of what's going on in the field so that they know where potentially they could identify and collect better evidence to add to this emerging evidence base. Ultimately it is quite a tricky space, and realistically when you are trying to do things that are good for your community, you have to make allowances and be pragmatic about how research is delivered.’

‘Overall, this was a huge and complex review that was really challenging to deliver but we’re so pleased we did,’ Natalie says. ‘I really have to hand it to the team though. It was their sheer persistence that delivered this review, and the reward now for us is having this really high quality piece of work that people from health services can use to show how effective their programs are. We wanted to support local services to advocate for themselves and now they can use this information as they need – either to show where they might need to make changes or to demonstrate that what they're doing is effective and benefits children, families and communities. They are really making a difference.’

Strobel NA, Chamberlain C, Campbell SK, Shields L, Bainbridge RG, Adams C, Edmond KM, Marriott R, McCalman J. Family‐centred interventions for Indigenous early childhood well‐being by primary healthcare services. Cochrane Database of Systematic Reviews 2022, Issue 12. Art. No.: CD012463. DOI: 10.1002/14651858.CD012463.pub2.

• Read the full systematic Review

Written by  Shauna Hurley, Cochrane Australia 

 

Thursday, January 19, 2023

Različiti načini liječenja ezotropije (otklon oka prema unutra) koja se javlja unutar prvih šest mjeseci života Koji je cilj ovog sustavnog pregleda? Cilj je ovog sustavnog pregleda bio ustanoviti je li jedan način liječenja (npr. kirurški ili nekirurški) bolji od drugoga za ezotropiju (otklon oka prema unutra) koja se javlja u djece unutar prvih šest mjeseci života. To se stanje zove infantilna ezotropija. Kako bismo dobili odgovor, pretražili smo baze podataka i pronašli dva relevantna istraživanja vezana uz liječenje infantilne ezotropije. Što se proučavalo u ovom sustavnom pregledu?...

Pomaže li smanjenje unosa soli u sprječavanju i liječenju kronične bolesti bubrega kod osoba s dijabetesom? Što je proučavano u ovom sustavnom pregledu? Postoje čvrsti dokazi da svi konzumiramo previše soli, što može povećati rizik za nastanak visokog krvnog tlaka. Ovo je osobito važno kod osoba oboljelih od dijabetesa jer dijabetes povećava rizik od moždanog i srčanog udara, te zatajenja bubrega. Visok krvni tlak će dodatno povećati te rizike. Smanjenje unosa soli bi moglo pomoći u snižavanju krvnog tlaka, umanjiti rizik od srčanog udara, te pogoršanja funkcije bubrega. Kako je proveden...

Smanjuju li kratka razdoblja umjetnog blokiranja dotoka krvi u udove smrtnost i ozljede organa kod ljudi kod kojih se planira vaskularna operacija? Ključne poruke • Izvođenje kratkih razdoblja opstrukcije dotoka krvi u udove prije operacije, putem napuhivanja manžeta za krvni tlak (udaljeno ishemijsko prekondicioniranje, engl. remote ischaemic preconditioning, RIPC), vjerojatno ne smanjuje smrtne ishode, ozljede organa, duljinu boravka u bolnici ili trajanje operacijskog zahvata kod ljudi kojima je potreban vaskularni zahvat (npr. liječenje suženja ili proširenja arterije). • Potrebno je...

Physical exercise can help to improve the severity of movement-related symptoms and the quality of life in people with Parkinson’s Disease. Findings from the first Cochrane review of the available evidence found that any type of structured exercise is better than none.

The Cochrane Movement Disorders review looked at 156 randomised controlled trials comparing physical exercise with no physical exercise or with different types of exercise, and it included a total of 7,939 people from around the world, making it the largest and most comprehensive systematic review to study the effects of physical exercise in people with Parkinson’s Disease. 

The review from Cochrane, a collaboration of independent, international experts, was led by Dr Elke Kalbe, Professor of Medical Psychology at the University of Cologne, Germany. It found that physical exercise ranging from dance, water-based exercise, strength and resistance exercise and endurance exercise, to tai chi, yoga and physiotherapy, made mild to large improvements to the severity of movement-related (‘motor’) symptoms and quality of life. 

“Parkinson’s Disease is a progressive disorder of the nervous system that mostly affects people over 60,” said Professor Kalbe. “Symptoms begin gradually and include movement problems such as trembling, stiffness, slowness of movement and balance, and lack of coordination. People can also have emotional and mood problems, fatigue, sleep problems and cognitive difficulties. Parkinson’s Disease cannot be cured, but the symptoms can be relieved, and physiotherapy or other forms of exercise may help too. Until now it has been unclear whether some types of exercise work better than others. We wanted to find out what exercise works best to improve movement and quality of life.”

The average age of the participants in the studies included in the review was between 60 and 74 years. Most had mild to moderate disease and no major impairment of their thinking processes. The review found that most types of exercise worked well for the participants compared to no physical exercise.

The first author of the review, Mr Moritz Ernst, is a member of Cochrane Haematology and deputy head of the working group on Evidence-based Medicine, which is led by co-author of the study, Professor Nicole Skoetz, at University Hospital Cologne. He said: “We observed clinically meaningful improvements in the severity of motor symptoms for most types of exercise. These included dancing, training to improve gait, balance and movement, multi-exercise training, and mind-body training.  

“We saw similar benefits in the severity of motor symptoms for water-based training, strength and resistance training, and endurance training, but the estimates of improvement were rather imprecise, meaning that we are not as confident in saying that these improvements are clinically meaningful.

“For the effects on quality of life, we observed clinically meaningful beneficial effects for water-based training, and effects that are probably clinically meaningful for several types of exercise, such as endurance training, mind-body training, training to improve gait, balance and movement and multi-exercise training. Again, these estimates were rather imprecise.”

The certainty in the estimates for the effects on symptoms from different forms of exercise varied because some studies were very small, and not all provided information on the severity of motor symptoms and quality of life for all the participants. However, the authors say that their review highlights that most types of exercise produced meaningful improvements, and they found little evidence of much difference between different exercises.

Prof. Kalbe said: “We think that our results are good news because they indicate that people with Parkinson’s Disease can benefit from various structured exercise programmes to improve the severity of motor symptoms and quality of life. Our review highlights the importance of physical exercise in general, while the exact exercise type may be secondary. Therefore, the personal preferences of people with Parkinson’s Disease should be given special consideration to help motivate them to adhere to an exercise programme. Any exercise counts! 

“It is important to point out that our conclusions do not rule out that certain motor symptoms may be treated most effectively by programmes, such as physiotherapy, that are designed specifically for people with Parkinson’s disease.”

Mr Ernst concluded: “Although our results are quite promising for people with Parkinson’s Disease, the certainty in the evidence on the efficacy of different exercise types and on potential differences between them, was usually limited. This was also because most studies had a very small sample size. Therefore, although there is already a large amount of research in this field, we would encourage researchers to conduct larger studies with clearly defined samples, as this would help to draw conclusions with more confidence. In addition, it would be admirable to see studies that focus on people with more advanced disease and thinking impairment, so that we could find out if physical exercise could also be beneficial for these people.”

Ernst M, Folkerts A-K, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis. Cochrane Database of Systematic Reviews 2023, Issue 1. Art. No.: CD013856. DOI: 10.1002/14651858.CD013856.pub2.

• Read the full review on the Cochrane Library
• Visit the Cochrane Movement Disorders website
• Press contact information
• Read the Evidently Cochrane blog post 'Physical exercise for people

Wednesday, March 15, 2023

Telerehabilitacija za slabovidne osobe Cilj Cochraneovog sustavnog pregleda Cilj ovog pregleda bio je procijeniti korisne učinke rehabilitacije vida na daljinu (putem telerehabilitacije) za slabovidne osobe. U telerehabilitaciji rehabilitacija vida se pruža putem interneta umjesto u ordinaciji, a slabovidne osobe se obučavaju kako poboljšale preostalu vidnu funkciju. Primarni cilj ovog pregleda bio je usporediti podatke iz upitnika o poboljšanju kvalitete života vezane uz vid. U fokusu je također bila vidna funkcija, poput sposobnosti čitanja, kao i usklađenost s planiranim treninzima i...

Baklofen za poremećaj zlouporabe alkohola Ključni rezultati sustavnog pregleda U ovom Cochraneovom sustavnom pregledu istražili smo dokaze o učinkovitosti i sigurnosti baklofena u liječenju osoba s poremećajem upotrebe alkohola (AUD, engl. Alcohol use disorder) u svrhu postizanja i održavanja apstinencije (prestanak konzumiranja alkohola) ili smanjenja konzumacije alkohola. Trenutačni dokazi upućuju na to da baklofen može pomoći osobama s AUD-om u održavanju apstinencije, osobito kod osoba koje su već detoksificirane. Rezultati usporedbi s drugim lijekovima pretežno su temeljeni na jednom...

Lijekovi za povećanje razine fetalnog hemoglobina i smanjenje potrebe za transfuzijom krvi kod pacijenata s talasemijom neovisnoj o transfuziji Cilj sustavnog pregleda Mogu li lijekovi koji povećavaju razinu fetalnog hemoglobina smanjiti potrebu za transfuzijom krvi kod pacijenata s beta-talasemijom neovisnoj o transfuziji (NTDβT)? Što je talasemija? Talasemija je genetski (nasljedni) poremećaj krvi koji uzrokuje promjene hemoglobina (komponente crvenih krvnih stanica zaslužne za prijenos kisika), što dovodi do uništenja eritrocita i različitih razina anemije. Trajna anemija utječe na...

Je li vitamin D učinkovit i siguran dodatak antibioticima u liječenju upale pluća kod djece? Što je to upala pluća i kako se može liječiti? Pneumonija je upala pluća uzrokovana infekcijom. Liječenje upale pluća uključuje korištenje antibiotika, opskrbu kisikom preko maske i druge pomoćne oblike terapije. Vitamin D jača imunosnu obranu i smanjuje prekomjernu upalu - takvi učinci potencijalno mogu pomoći djeci u oporavku od epizode upale pluća. Cilj ovog sustavnog pregleda Htjeli smo saznati hoće li uporaba vitamina D zajedno s antibioticima pomoći djeci u oporavku od upale pluća. Kako je...