Koliko su točne virtualne procjene na daljinu u dijagnosticiranju demencije? Zašto je ovo pitanje važno? Demencija je kronično i progresivno stanje koje utječe na ljudsko pamćenje i sposobnost svakodnevnog funkcioniranja. Klinička dijagnoza demencije obično uključuje snimanje mozga, fizikalne preglede i uzimanje anamneze. Kao prvi korak, često koristimo testove pamćenja i razmišljanja kako bismo identificirali osobe kojima je potrebna daljnja procjena. Tradicionalno ovi se testovi izvode uživo, ali modifikacije testova dopuštaju korištenje telefonom ili putem videopoziva – što se ponekad...

Usporedba uskopojasnog snimanja s običnom cistoskopijom za liječenje raka mokraćnog mjehura Istraživačko pitanje Kako se resekcija tkiva mokraćnog mjehura vođena posebnom metodom vizualizacije koja se zove uskopojasno snimanje može usporediti s resekcijom tkiva mokraćnog mjehura vođenom standardnom metodom vizualizacije (koristeći bijelo svjetlo) u osoba s tumorima unutarnje stijenke mjehura? Dosadašnje spoznaje Kada postoji sumnja na rak mokraćnog mjehura ili uz već postavljenu dijagnozu raka mokraćnog mjehura, liječnici moraju pomno pregledati mjehur i uzeti tkiva radi daljnje analize....

Specifications: Full Time 1 year Fixed Term contract
Salary:  £42,000 per annum
Location: UK based (remote)
Application Closing Date: 25 April 2022 (9am GMT)

Cochrane is a global independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making the vast amounts of evidence generated through research useful for informing decisions about health. We do this by identifying, appraising and synthesizing individual research findings to produce the best available evidence on what can work, what might harm and where more research is needed.

A Project Manager role has become available to support the Evidence Production and Methods Department (EPM), Publishing and Technology department (P&T), Cochrane Library Product Manager and other Central Executive Teams (CET) in delivering on high priority projects: to project manage the highest priority EPM, P&T and other Cochrane projects where appropriate.

Key essential criteria we are looking for:

• Project Management qualification
• Publishing experience
• 2-4 years’ experience in project management, change management and risk management. Proven track record in delivering projects
• Experience of Agile project management methodology
• Experience with project management software tools e.g. Microsoft Project, JIRA, Confluence, SmartSheets

For further information on the role and how to apply, please click here.  The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples. Note that we will assess applications as they are received, and therefore may fill the post before the deadline.

Deadline for applications: Monday 25 April 2022 (9am GMT).

Thursday, April 7, 2022 Category: Jobs

Cochrane’s Governing Board is pleased to announce the appointment of Catherine Spencer as Cochrane’s new Chief Executive Officer. 

Catherine joins Cochrane from The Seafarers’ Charity where she held the position of CEO.

Prior to her role at The Seafarers’ Charity, Catherine was acting Chief Operating Officer and Director of Communications and Change Management at international public health research organisation, icddrb, in Dhaka, Bangladesh. Between 2008-2015 Catherine held various senior management roles at the Army Families Federation, including three years as Chief Executive.

Governing Board Co-Chairs, Tracey Howe and Catherine Marshall said: "We are delighted to welcome Catherine to Cochrane. Catherine is a proven Chief Executive with an exceptional record leading non-profit organisations. She brings expertise in strategic planning, change management, and communications backed by a global perspective. Catherine is well positioned to partner with the Editor-in-Chief, Karla Soares-Weiser, to lead Cochrane as we drive an exciting programme of delivering trusted evidence, promoting informed decisions, and better health.”

Catherine lives with her family in Wiltshire, England after many years moving frequently, including living and working in Canada, Germany, Cyprus and Bangladesh.

Catherine will take up the position as CEO in July 2022.

• Read Catherine’s full bio

Thursday, April 7, 2022

Sustavni pregled o lijeku takrolimusu za liječenje ulceroznog kolitisa koji se teško liječi Cilj Cochraneovog sustavnog pregleda Željeli smo saznati je li takrolimus učinkovit i siguran lijek u osoba s ulceroznim kolitisom koji se teško liječi na bilo koji drugi način. Dosadašnje spoznaje Ulcerozni kolitis je kronična upalna bolest crijeva obilježena ponavljajućim epizodama aktivne bolesti, koje obično pogađaju rektum ili debelo crijevo ili oboje. Osobe s aktivnom bolešću mogu imati grčeve u trbuhu, pojačani nagon za stolicom i krvavi proljev. Standardni oblici liječenja za aktivnu bolest...

Medicinske intervencije za liječenje kronične upale nosa i sinusa u cističnoj fibrozi Istraživačko pitanje Kakvi su učinci medicinskih intervencija za kronični rinosinuitis na osobe s cističnom fibrozom? Dosadašnje spoznaje Kronični rinosinusitis dugotrajna je infekcija i upala nosne šupljine i prostora oko očiju i nosa koji su ispunjeni zrakom. Cistična fibroza genetska je bolest zbog koje sekreti u tijelu postaju gusti i zbog toga zaostaju. Kada se to dogodi unutar i oko nosa, to izaziva kronični rinosinusitis. Bolja briga o osobama s cističnom fibrozom produžila je njihov životni vijek,...

Ponovljene doze prenatalnih kortikosteroida za žene s rizikom od prijevremenog poroda za poboljšanje neonatalnih zdravstvenih ishoda Što je proučavano u ovom sustavnom pregledu? Novorođenčad rođena prije termina (prije 37. tjedna trudnoće) izložena je riziku od otežanog disanja i bolesti pluća jer njihova pluća nisu u potpunosti razvijena. Jedna doza prenatalnih (primijenjenih tijekom trudnoće) kortikosteroida, koja se daje ženama koje bi mogle rano roditi, pomaže u razvoju djetetovih pluća i poboljšava preživljavanje. Ovaj korisni učinak ne traje dulje od sedam dana, tako da su bebe rođene...

Kontinuirani pozitivni tlak dišnih puteva (CPAP) za akutni bronhiolitis u djece Pitanje sustavnog pregleda Je li kontinuirani pozitivni tlak na dišne puteve (engl. continuous positive airway pressure, CPAP) bolji ili lošiji od simptomatske terapije za djecu koja pate od akutnog bronhiolitisa? Dosadašnje spoznaje Bronhiolitis je upala malih dišnih puteva u plućima i čest uzrok bolničkog liječenja male djece. Djeca s akutnim bronhiolitisom obično primaju simptomatsku terapiju koja uključuje odgovarajuću hidraciju te davanje dodatnog kisika ako je to potrebno. Liječenje pomoću CPAP metode...

Jesu li instrumenti sa videokamerom za umetanje cijevi za disanje kod odraslih bolji od instrumenata s izravnim pogledom i uzrokuju li neželjene učinke? Ključne poruke Uređaji koji se nazivaju laringoskopi koriste se kao pomoć medicinskom osoblju da umetnu plastičnu cijev za disanje u nečiji dušnik jer im je potrebna pomoć pri disanju. Na uređaj se može priključiti video kamera. Otkrili smo da videolaringoskopi općenito poboljšavaju uspjeh umetanja cijevi za disanje u usporedbi s konvencionalnim laringoskopima. Što je intubacija? Ljudi koji su jako bolesni ili imaju operaciju pod općom...

Kontrolne intervencije u randomiziranim ispitivanjima za osobe s mentalnim poremećajima Ovaj sustavni pregled procjenjuje učinak različitih kontrolnih intervencija u randomiziranim ispitivanjima koja uključuju pacijente s mentalnim poremećajima. U randomiziranim ispitivanjima pacijenti su nasumično podijeljeni u jednu od dvije ili više skupina - obično u intervencijsku skupinu i kontrolnu skupinu. Postoji veliki broj kontrolnih intervencija u istraživanjima za mentalno zdravlje. Jedne od najčešćih kontrolnih intervencija su različiti tipovi placeba u kojima nedostaje ono što se podrazumijeva...

Postupno (temeljeno na algoritmu) liječenje boli za osobe s demencijom koje žive u staračkim domovima Cilj Cochraneovog sustavnog pregleda Zanimalo nas je kako medicinske sestre mogu najbolje kontrolirati bol kod osoba s demencijom koje žive u domovima za starije osobe. Liječenje boli uključuje mjerenje boli i liječenje boli ukoliko je to potrebno. Zanimalo nas je mogu li postupne upute (algoritam) za medicinske sestre o tome kako liječiti bol smanjiti bol ili ponašanje koje može ukazivati na to da je netko pod stresom (kao što je udaranje, vikanje ili lutanje). Što je bilo proučavano u ovom...

Intervencije za liječenje infekcija krvotoka povezanih s kateterom u pacijenata na hemodijalizi Što je proučavano u ovom sustavnom pregledu? Bolesnici sa zatajenjem bubrega zahtijevaju nadomjesnu bubrežnu terapiju (NBT). Među NBT opcijama, hemodijaliza (HD) je primarna metoda dijalize. Pacijenti koji primaju HD putem stalnog katetera imaju veći rizik od razvoja infekcija krvotoka. Postoji nekoliko opcija za liječenje ovih infekcija krvotoka. One uključuju otopine za zaključavanje katetera (infuzije visokih doza antibiotika unutar svakog otvora katetera između dijaliznih postupaka),...

Grant to enhance evidence-informed guideline recommendations for newborn and young child health in South Africa, Malawi and Nigeria

The Global Evidence, Local Adaptation project aims to maximise the impact of evidence for poverty-related diseases by increasing the capacity of decision makers and researchers to use global research to develop locally relevant guidelines for newborn and child health. The project will support decision makers in South Africa, Malawi and Nigeria, and will build on and add value to the large-scale programme of child-health guideline development led by the World Health Organization (WHO), with adaptation and implementation led by the WHO Afro regional office, country offices and national ministries.

 “Despite progress in the health of newborns and children, most sub-Saharan African countries have not met the Sustainable Development Goals for under-five mortality,” said Tamara Kredo of Cochrane SA. “In the context of COVID-19, even though most children present with mild conditions, the consequences of the pandemic are being felt on health systems and services, hampering healthcare delivery to children and increasing poverty, food insecurity and inequity. To address these issues, policy makers and practitioners not only need evidence-based guidance on effective clinical care, they also need guidance on how to implement this care efficiently within the context of their own health systems, considering inequity (in health and access to services) caused by poverty and other factors.”

“MAGIC is thrilled to be partner in GELA,” said Per Olav Vandvik. “The need to allow WHO guidelines to make an impact in member states is critical. Now is the time to show this is possible and we believe this strong consortium of partners is excellently placed to get the work done.”

“Clinical practice guidelines offer a means to bridge the gap between research evidence and practice and are essential policy-implementation tools supporting implementation of effective, cost-effective healthcare,” added Kredo.

The European and Developing Countries Clinical Trials Partnership (EDCTP) has awarded three-year (2022 – 2025) funding of over 3 million Euro to a partnership coordinated by Cochrane South Africa (SA), South African Medical Research Council along with partners from the Norwegian Institute of Public Health, The Norwegian University of Science and Technology, Western Norway University of Applied Science, Stellenbosch University (South Africa), Cochrane Nigeria at the University of Calabar Teaching Hospital, Kamuzu University of Health Sciences (Malawi), Cochrane and the Stiftelsen MAGIC Evidence Ecosystem (Norway).  

 The specific objectives are to: 

1. ENGAGE: Identify child and newborn priority topics and the capacity needs of guideline panels. 
2. SYNTHESISE: Support policy makers and researchers to find, appraise and use best-available systematic reviews and guidelines. 
3. DECIDE: Support guideline panels’ capacity to contextualise global evidence using transparent, digitally supported standards and WHO methods for guideline development. 
4. SHARE: Disseminate and communicate guideline recommendations to healthcare providers and the public using innovative and user-friendly formats and digital platforms.
5. LEARN: Strengthen capacity of researchers and policy makers for all aspects of guideline development, adaptation and dissemination. 
6. EVALUATE: Monitor and evaluate policy makers’ experiences of this approach, preferences for receiving evidence, capacity development and overall impact of the project on evidence-informed decision-making processes. 

GELA will incorporate a multi-faceted, multidisciplinary research and capacity-strengthening programme using primary and secondary research, guideline-adaptation methodology and digital platforms to support delivery and dynamic local adaptation. This is enabled through a project team of African and international leaders in the field of evidence-based healthcare and guidelines methods partnering with national ministries in Malawi, Nigeria and South Africa, the WHO and its Afro regional office and the civil society group, Peoples Health Movement.

The European and Developing Countries Clinical Trials Partnership (EDCTP) is a public-public partnership between countries in Europe and sub-Saharan Africa, supported by the European Union. EDCTP focuses on enhancing research capacity and accelerating the development of new or improved medical interventions for the identification, treatment and prevention of poverty-related infectious diseases, including emerging and re-emerging diseases in sub-Saharan Africa, through all phases of clinical trials, with emphasis on phase II and III trials. 

 This project is part of the EDCTP2 programme supported by the European Union (grant number RIA2020S-3303-GELA).

 ABOUT THE PARTNERS

Cochrane South Africa

Cochrane South Africa (SA) is an intramural research unit of the South African Medical Research Council and is part of the global, independent Cochrane network of researchers, professionals, patients, carers and people interested in health. It aims to promote evidence-informed healthcare decision-making in South Africa and sub-Saharan Africa by producing high-quality, relevant, accessible systematic reviews and other synthesised research evidence.

https://southafrica.cochrane.org/about-us

Cochrane

Cochrane focuses on producing relevant and timely synthesised evidence and is a global advocate for evidence-informed health and health care. We work towards a world of improved health where decisions about health and health care are informed by high-quality, relevant and up-to-date synthesised research evidence. Our members and supporters come from more than 130 countries, worldwide.

https://www.cochrane.org/

MAGIC

The independent non-profit Norwegian MAGIC Evidence Ecosystem Foundation was set up in 2018 to provide sustainable and professional services to our customers (e.g. MAGICapp) while pursuing the evidence ecosystem vision through continued research and innovation.

MAGIC leads the work package on disseminating and communicating CPG recommendations to healthcare providers and the public. GELA will make use of innovative formats and the MAGIC authoring and publication platform (MAGICapp) to adapt, translate WHO guidelines for national and local use. MAGIC will also support development and adaptation of the guideline recommendations, customised to the needs of decision makers and making use of the GRADE EtD framework.

https://magicevidence.org/

Centre for Evidence-based healthcare, Stellenbosch University

The CEBHC is a recognised leader nationally and globally for research and practice in teaching and learning for evidence-based health care (EBHC). Based at the Faculty of Medicine and Health Sciences they support undergraduate and post-graduate training in all aspects of EBHC. They lead a Masters in Clinical Epidemiology programme recognised throughout the continent. Leads at SU have spearheaded several projects linked to evidence synthesis, knowledge translation, building capacity of policymakers and researchers for evidence-informed policymaking, and supported national and international guideline projects.  

https://www.cebhc.co.za/

NIPH

The Norwegian Institute of Public Health (NIPH) acts as a national competence institution placed directly under the Ministry of Health and Care Services. Our social mission is to provide knowledge and systematic reviews to contribute to good public health efforts and healthcare services. In this way we contribute to better health, both in Norway and globally.

https://www.fhi.no/en/

Cochrane Nigeria

Cochrane Nigeria at the University of Calabar Teaching Hospital's Institute of Tropical Disease Research and Prevention is involved in the production and dissemination of relevant and priority systematic reviews of healthcare interventions, provision of technical support for development of trustworthy clinical practice guidelines and knowledge translation activities involving the media. Our long term strategic goal is to strengthen stakeholders' capacity to use evidence to inform decisions for positive individual and population health outcomes within Nigeria and the West African sub-region.

https://nigeria.cochrane.org/

Kamuzu University of Health Sciences

Kamuzu University of Health Sciences (KUHeS) is a public-owned university established in 2019 under the act of parliament by merging the Kamuzu College of Nursing (est. 1979) and College of Medicine (est. 1991). As a key government partner, the university continues to serve the Malawi nation through provision of quality education and innovation through research as key to the health welfare of Malawi, the region and beyond. Through research the university generates evidence that informs government policies and practice in the health sector. KUHeS is an internationally recognised institution currently leading the teaching of systematic reviews, evidence-based healthcare and formulation of evidence-informed health guidelines in Malawi.

www.kuhes.ac.mw 

Wednesday, April 6, 2022

Tuesday, March 29, 2022

Žica vodilica ili kontrast: što je bolje za sprječavanje pankreatitisa nakon retrogradne kolangiopankreatografije? Ključne poruke: • Endoskopska retrogradna kolangiopankreatografija (ERCP) kombinira endoskopiju i rendgenske snimke za dijagnosticiranje i liječenje problema žučnih i gušteračnih kanala. U usporedbi s tradicionalnom tehnikom koja uključuje ubrizgavanje kontrastne boje u kanale s kateterom, korištenje tehnike žice vodilice za pristup žučnom kanalu vjerojatno smanjuje rizik od post-ERCP pankreatitisa (PEP) i također može povećati stopu uspješnosti pristupa do žučnog kanala. •...

Radna terapija za kognitivne poremećaje u osoba koje su imale moždani udar Cilj Cochraneovog sustavnog pregleda Cilj ovog Cochraneovog sustavnog pregleda bio je otkriti poboljšava li radna terapija funkciju u svakodnevnim aktivnostima i kognitivne procese nakon moždanog udara. Spoznaja je obrada informacija koju provodi mozak, kao što je razmišljanje, obraćanje pažnje na stvari koje vidite ili čujete, učenje, pamćenje i rješavanje problema. Cochraneovi istraživači prikupili su i analizirali sva relevantna istraživanja o ovoj temi i pronašli 24 istraživanja. Ključne poruke Za osobe s...

Probiotici za liječenje kroničnog zatvora (konstipacije) u djece Cilj Cochraneovog sustavnog pregleda Cilj ovog Cochraneovog sustavnog pregleda bio je otkriti mogu li se probiotici koristiti za liječenje kroničnog zatvora bez fizičkog objašnjenja kod djece (u dobi od 0 do 18 godina). Analizirani su podaci iz 14 istraživanja kako bi se odgovorilo na to pitanje. Ključne poruke Autori nisu uspjeli donijeti zaključke o liječenju probioticima naspram liječenja placebom za učestalost pražnjenja crijeva u djece liječene od kroničnog zatvora bez fizičkog objašnjenja. Moguće je da nema razlike u...

Lijekovi za smanjenje upale kod osoba s obiteljskom mediteranskom vrućicom Istraživačko pitanje Može li liječenje kolhicinom, anakinrom, rilonaceptom, kanakinumabom, etanerceptom, infliksimabom, adalimumabom, talidomidom, tocilizumabom, interferonom-α i ImmunoGuardom (biljnim dodatkom) umanjiti upalu kod osoba s obiteljskom mediteranskom vrućicom (engl. familial Mediterranean fever, FMF)? Dosadašnje spoznaje Obiteljska mediteranska vrućica je nasljedna upalna bolest sa simptomima koji uključuju vrućicu iznad 38℃, bol i upalu opne koja okružuje prsnu šupljinu, zglobove ili pluća. Cilj ovog...

Specifications: Full Time (Permanent)
Salary: £60,000 per annum
Location: Flexible, UK
Application Closing Date:  Friday 15 April 2022

A wonderful new opportunity has come up on the team at Cochrane, a brilliant not-for-profit publishing organisation that facilitates global medical research. They are now looking for a new Head of Editorial who will lead the editorial operations and oversee the transition of editorial processes to a centralised system. With lots of change and growth planned, this is an exciting opportunity to join an expanding team and be involved with the strategic direction and leadership of the team.
 
Reporting into the Editor in Chief, you will have responsibility for:

• Overseeing a small team of direct and indirect reports
• Managing editorial operations for articles submitted, contributing to the development of new processes for direct submissions
• Attending editorial board meetings as part of senior management team
• Contributing to the editorial strategy for the launch of new journals and supplementary products
• Facilitating communication and collaboration among different directorates 

The ideal candidate will possess strong leadership skills and the ability to manage relationships with key stakeholders both internal and external to the business. Candidates applying do need experience with Editorial Manager as this is a new system which has been implemented. They will ideally come from an scholarly publishing background - ideally STM, and understand the importance of systematic reviews, research platforms and digital resources, and their role within research. Some experience of line management and budget management will be great, together with familiarity with a charity organisation or the healthcare sector.

Cochrane is a global, independent network of health practitioners, researchers, patient advocates and others, responding to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesizing research findings to produce the best available evidence on what can work, what might harm and where more research is needed. Our work is recognised as the international gold standard for high quality, trusted information. An understanding of Cochrane’s work and health research more generally is an advantage, but not essential.

How to apply
If you're interested in finding out more about this great role, get in touch with Shalini Bhatt at Inspired Selection with your CV via s.bhatt@inspiredselection.com.

Friday, March 25, 2022 Category: Jobs

The World Health Organization (WHO) has issued an updated postnatal guideline which is supported by evidence from Cochrane Pregnancy and Childbirth reviews and one Cochrane Incontinence review.

Cochrane has been a non-governmental organization in official relations with WHO since 2011, and a major aspect of this partnership is supporting WHO’s global health guidelines with relevant evidence synthesis.

The Cochrane Pregnancy and Childbirth Group has a long-standing collaboration with WHO on the development and updating of Cochrane reviews that inform WHO’s guidelines on global maternal and perinatal health.

In March 2022, WHO released the updated comprehensive guideline called ‘WHO recommendations on maternal and newborn care for a positive postnatal experience’. It focuses on the weeks shortly after the birth and makes 63 recommendations on maternal care, newborn care, health systems, and health promotion during the postnatal period.

The guideline draws on the evidence from a suite of systematic reviews and qualitative evidence syntheses, including 13 Cochrane Reviews. These Cochrane Reviews cover:

• Relief of postpartum pain (5 reviews; 3 recommendations) 
• Pelvic floor muscle training for pelvic floor strengthening (1 review; 1 recommendation) 
• Preventing and treating breast engorgement and mastitis (2 reviews; 4 recommendations) 
• Preventing postpartum constipation (1 review; 1 recommendation) 
• Vitamin D supplementation for term breastfed infants (1 review; 1 recommendation)
• Timing of discharge from health facilities to the home (1 review; 1 recommendation)
• Schedules for postnatal care contacts (1 review; 2 recommendations)

As well as the 12 Cochrane Reviews, a Cochrane qualitative evidence synthesis on the factors that influence the provision of postnatal care was used to help understand the acceptability and feasibility of different aspects of postnatal care, according to health workers. 

The Cochrane evidence highlights the broadened scope of the guideline, and sheds important light on some of the most common experiences of women after having a baby.

Evidently Cochrane Author Jessica Hatcher-Moore with her first baby at home, days after giving birth. Jessica had a positive first experience of birth but felt poorly prepared for what came next. Image: © Philip Hatcher-Moore

“The WHO guideline sets out clear recommendations around the common health issues women experience after giving birth. It brings renewed and due focus to the importance of a positive postnatal experience at the heart of care - because no woman should ever feel abandoned by health services after having a baby”, says Aleena Wojcieszek, a clinical epidemiologist, science communicator, and honorary research fellow at the Australian Centre of Research Excellence in Stillbirth (Stillbirth CRE). “I was excited to highlight the need for real investment in postnatal care and urgent need for high-quality research in a recently Evidently Cochrane blog. It’s written jointly with Jessica Hatcher-Moore, a new mother, and illustrates how good postnatal care should aim to meet every individual woman’s needs, leaving the new mother, her baby and family with a positive experience of this critical period in their lives.”

"Cochrane is extremely proud of this valuable work and our continued partnership with WHO", said Dr Karla Soares-Weiser, Editor in Chief of the Cochrane Library. "This particular collaboration makes it possible to translate the latest maternal and perinatal health evidence into practice quickly, which ultimately benefits more people's health."

• Read 'WHO recommendations on maternal and newborn care for a positive postnatal experience' 
• Read the Evidently Cochrane blog: 'Putting positive experiences at the centre of postnatal care' 
• Visit the Cochrane Pregnancy and Childbirth website
• Visit the Cochrane Incontinence website

 

Wednesday, March 30, 2022 Category: The difference we make