Koliko su točni rezultati FIB-4 i Fornsovog indeksa (neinvazivni testovi) u dijagnosticiranju stadija fibroze (ožiljaka) jetre kod odraslih s kroničnim hepatitisom C? Ključne poruke • U početnoj fazi ispitivanja o prisutnosti ožiljnih promjena na jetri mogu se koristiti i FIB-4 rezultat i Fornsov indeks. • Najbolje je koristiti FIB-4 rezultat kako bi se isključio stadij 3 (teška fibroza) ili stadij 4 fibroze (ciroza). • Najbolje je koristiti Fornsov indeks za dijagnosticiranje osoba sa stadijem 2 fibroze (značajna fibroza). Zašto je važno poboljšati dijagnostiku ožiljkavanja jetre? Infekcija...

Je li imunoterapija uz kemoterapiju bolja od same kemoterapije za starije osobe s rakom pluća nemalih stanica? Ključne poruke • Za osobe od 65 godina i starije s uznapredovalim rakom pluća nemalih stanica (engl. non-small cell lung cancer, NSCLC) koji prethodno nisu bili liječeni od raka, dodavanje imunoterapije kemoterapiji produljuje život i produljuje vrijeme življenja bez progresije tumora. Ovo otkriće dolazi iz istraživanja koja su uglavnom uključivala osobe dobi između 65 i 75 godina. • Nismo pronašli te iste korisne učinke dodavanja imunoterapije kemoterapiji kod ljudi starijih od 75...

Je li transarterijska (kemo)embolizacija bolja od sistemske kemoterapije za liječenje raka crijeva koji se proširio na jetru? Ključne poruke – Transarterijska kemoembolizacija (skraćeno TACE) je metoda uništavanja stanica raka davanjem lijekova protiv raka i sitnih kuglica koje izravno blokiraju dotok krvi u tumor ili davanjem kuglica koje su obložene lijekom protiv raka. TACE može smanjiti smrtnost u usporedbi s lijekom protiv raka koji se daje injekcijom u krvnu žilu te putuje cijelim tijelom do stanica (naziva se sistemska kemoterapija), ali dokazi o tome su vrlo nesigurni. TACE može...

Wednesday, August 7, 2024

Jesu li matične stanice uzete iz koštane srži i isporučene u srce siguran i učinkovit tretman nakon srčanog udara? Ključne poruke - Liječenje matičnim stanicama ne dovodi do poboljšanja kliničkih ishoda kod osoba koje su imale srčani udar. - Terapija dovodi do nekoliko neželjenih ili štetnih učinaka za vrijeme liječenja. Uvod Srčani udari nastaju zbog začepljenja arterije koja krvlju opskrbljuje srčani mišić. Iako nove terapije napreduju, mnogi ljudi koji su imali srčani udar imaju smanjenu srčanu funkciju i kraći životni vijek. Dosadašnje spoznaje Trenutačno je standardni tretman za osobe...

Tuesday, August 6, 2024

Usporedba tretmana kože za ekcem Ključne poruke: ° Jaki kortikosteroidi, JAK inhibitori i 0,1%-tni takrolimus (lijekovi koji suzbijaju imunosni sustav) dosljedno su učinkoviti u smanjenju znakova i simptoma ekcema. ° Neželjeni učinci, poput pečenja i peckanja, vjerojatniji su s takrolimusom, pimekrolimusom i krisaborolom, a manje s kortikosteroidima; drugi neželjeni učinci, poput stanjivanja kože, vjerojatni su samo ako se jaki kortikosteroidi koriste dugotrajno. ° S obzirom na neizvjesnost o dugoročnoj učinkovitosti i sigurnosti, treba uzeti u obzir druge čimbenike kao što su dostupnost,...

Koliko su precizni rutinski laboratorijski testovi u predviđanju smrtnosti i pogoršanja do teškog ili kritičnog oblika COVID-19 bolesti kod osoba sa SARS-CoV-2 infekcijom? Što su rutinski laboratorijski testovi? Rutinske laboratorijske pretrage/testovi skup su uobičajenih pretraga krvi koje daju informacije o zdravstvenom stanju pacijenta. Ovi se testovi mogu koristiti za prepoznavanje bolesti ili praćenje zdravlja. Cilj ovog sustavnog pregleda Važno je identificirati pacijente na liječničkom pregledu u ambulanti ili hitnoj službi koji su u visokom riziku od razvoja teškog oblika bolesti...

Cenobamat kao dodatak liječenju fokalne epilepsije kad dugotrajna uporaba lijekova protiv napadaja ne daje rezultate Ključne poruke - Kad se kombinira s jednim ili više lijekova protiv napadaja, cenobamat je vjerojatno bolji od placeba (lažna terapija) u smanjenju učestalosti epiletičkih napadaja za najmanje 50% i u prestanku napadaja u odraslih s fokalnom epilepsijom kod kojih dugotrajno liječenje lijekovima protiv napadaja ne daje rezultate. - Upotreba cenobamata vjerojatno uzrokuje više neželjenih nuspojava od placeba. Što je proučavano u ovom sustavnom pregledu? Epilepsija je bolest...

Specifications: Fixed-term contract (12 months) – part time
Salary: £35,000 per annum full time equivalent (to be pro rated)
Location: Remote working (UK, Germany or Denmark)
Closing date:  9 August 2024
    
Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters around the world. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into five directorates: Evidence Production and Methods, Publishing and Technology, Development, Central Executive office and Finance and Corporate Services.

The Consumer Support Officer will work closely with Cochrane’s Consumer Engagement Manager to support the involvement of consumers (patients, carers and the public) in the Wellcome-funded Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis (GALENOS) project, including in systematic reviews about mental health topics. Support of consumers in this work will involve connecting consumers with lived experience of mental health challenges to researchers, developing learning resources to support consumer involvement in systematic reviews, and generally promoting patient and public involvement in the systematic review space.
      
Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organization is built on four core values: Collaboration: Underpins everything we do, locally and globally. Relevant: The right evidence at the right time in the right format. Integrity: Independent and transparent. Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

• An opportunity to truly impact health globally.
• A flexible work environment
• A comprehensive onboarding experiences.
• An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

• For further information on the role and how to apply click here,  
• The deadline to receive your application is 9 August, 2024.
• The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
• Read our Recruitment Privacy Statement

Wednesday, July 31, 2024 Category: Jobs

Cochrane's strength lies in its collaborative, global community. Cochrane Geographic Groups represent Cochrane in their host countries, advocating for the use of Cochrane evidence in health policy and practice, and supporting Cochrane's members and supporters locally. Here, we spotlight the impactful work of Cochrane Iran, dedicated to increasing the use of best evidence to inform healthcare decision-making across Iran, the Middle East, and neighbouring regions. 

Established in 2017 at the National Insititute for Medical Research Development (NIMAD), Cochrane Iran has swiftly become a pivotal part of Cochrane's global network. By aligning with Cochrane's strategy, Cochrane Iran has significantly expanded its membership, growing from 965 members in 2019 to over 2,100 by mid-2024. 

Cochrane Iran has been a leader in providing hands-on learning through 50 in-person and virtual training sessions and contributed in the nine Continuing Medication Education events, furthering professional development in evidence-based healthcare. They share Cochrane’s recorded online learning events on Aparat, a local video-sharing platform, where the 671 videos have attracted 42,573 views. They co-authored the 4th and 5th editions of the influential book Systematic Review and Meta-Analysis, now a reference in national University courses. In collaboration with Iranian universities, they hosted five journal club sessions, promoting critical evaluation of research findings.

"Our mission at Cochrane Iran is to bridge the gap between research and practice by making high-quality evidence accessible and understandable. We believe that informed decision-making can transform healthcare outcomes across the Middle East."

— Dr. Farid Najafi, Director of Cochrane Iran

Cochrane Iran spearheaded the translation of numerous evidence-based resources, including:

• Over 6,000 abstracts and plain language summaries of Cochrane reviews.
• 72 podcasts explaining Cochrane evidence in under five minutes.
• 27  blogshots for social media that summarize Cochrane reviews.
• Persian Wikipedia pages related to medicine, such as asthma and influenza. 
• Testing Treatments book and audio clips, which champion critical thinking in healthcare.
• The Health Choices Book for children, fostersing critical thinking from a young age.
• Lifeology flashcard courses on preventing infodemics and empowering informed decision-making.
• World Evidence-Based Heathcare Day documents, promoting evidence-based healthcare globally annually.

Their advocacy and dissemination efforts extended to showcasing Cochrane and Cochrane Iran through 50 events and establishing a robust online presence on multiple platforms including Telegram, X, Instagram, and LinkedIn, engaging a large community and promoting evidence-based healthcare practices.

Cochrane Iran actively collaborated with the 10th Iranian National Epidemiology Congress in 2023, featuring a keynote speech by Cochrane CEO Catherine Spencer and leading a thematic panel on adapting WHO guidelines, evidence-based medicine, and Cochrane Iran's achievements. They also this year organised a citizen science challenge on Cochrane Crowd. Participants classified 78,692 records, identifying around 4,000 randomized controlled trials that will aid systematic reviewers worldwide in their research.

Cochrane Iran’s partnership with NIMAD has led to the launch of the Cochrane Evidence Synthesis in the Iranian Primary Health Care System project. This project has included the translation and local adaptation of the Cochrane Evidence Essentials training course, accessible on Iran's Ministry of Health's website, to promote evidence-based decision-making in primary healthcare settings and empower healthcare professionals with essential skills in evidence synthesis.

Their website, Barpaye, provides scientifically evaluated health claims, answering 49 user queries to date. They also sponsor the fact-checking website Factname Salamat, offering evidence-based answers to health-related questions and claims. 

"Through our collaborative efforts and the translation of essential healthcare resources, we are not only empowering healthcare professionals but also engaging the public in critical thinking about their health. This comprehensive approach is key to advancing evidence-based healthcare in Iran and beyond."

— Dr. Bita Mesgarpour, Co-Director of Cochrane Iran

Cochrane Iran remains dedicated to Cochrane’s vision of enhancing evidence-based healthcare quality and fostering collaboration within the research community. Through their continued efforts, they aim to significantly improve health outcomes and support informed decision-making in healthcare practices.

Cochrane Iran invites individuals and organisations to collaborate and support their mission of advancing evidence-based healthcare in the Middle East. Reach out to CochraneIran@gmail.com and explore the numerous opportunities to contribute to their impactful work. 

• Visit the Cochrane Iran website
• Search and view Cochrane evidence in Persian (Farsi)
• Follow Cochrane Iran on social media
  
  • Aparat
  • Instagram
  • LinkedIn
  • Telegram
  • X
• Find a Cochrane Geographical Group in your country

Friday, August 2, 2024

Jesu li kirurški zahvati za liječenje čukljeva (kurjih očiju) bolji od nekirurških načina liječenja? Ključne poruke – Kirurški zahvat može dovesti do smirivanja boli i blagog poboljšanja u funkciji te zadovoljstva liječenjem u usporedbi s nekirurškim liječenjem ili nikakvim liječenjem. Rizik od komplikacija koje se mogu pojaviti kod kirurških zahvata, kao što su inficiranje rane ili iritacija zbog kirurški ugrađenih dijelova zbog koje je potrebna dodatna operacija, treba uzeti u obzir pri razmatranju ovih korisnih učinaka. Što je čukalj (hallux valgus)? Čukljevi su koštana kvržica koja se...

Je li ultrazvuk sam ili u kombinaciji s drugim metodama koristan za potvrdu položaja želučane sonde? Ključne poruke – Neizvjesno je nudi li ultrazvuk obećavajuću alternativu rendgenu za potvrdu pravilnog položaja želučane sonde. – Potrebna su dodatna istraživanja kako bi se odredila točnost ultrazvuka u prepoznavanju pogrešno postavljenih sondi. Što su želučane sonde i zašto se koriste? Jednjak je mišićna cijev koja povezuje usta sa želucem. Ako osoba ne može pravilno gutati, moguće je umetnuti želučanu sondu kroz nos ili usta kako bi se lijekovi ili tekuća hrana unijeli izravno u želudac....

Title: Managing Editor
Specifications: 12 Months Fixed Term Contract (x 3 posts)
Salary: £42,000 per annum
Location: UK, Germany or Denmark – Remote/Flexible
Directorate: Evidence Production & Method
Closing date: 26 July, 2024

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters around the world. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into five directorates: Evidence Production and Methods, Publishing and Technology, Development, Chief Executive Office and Finance and Corporate Services.

Reporting to the Senior Managing Editor and working with members of the Editorial Production and Methods Directorate, the role holder will need to have good awareness of Cochrane guidance for different types of standard and complex systematic reviews (intervention, qualitative, diagnostic test accuracy, prognosis, rapid and overview), plan how they will need to be handled in their team, and work to ensure that deadlines are met. The role holder will also be required to ensure that pilots aimed at innovating the editorial process can be supported as needed.

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organization is built on four core values:

Collaboration: Underpins everything we do, locally and globally.

Relevant: The right evidence at the right time in the right format.

Integrity: Independent and transparent.

Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

• An opportunity to truly impact health globally.
• A flexible work environment
• A comprehensive onboarding experiences.
• An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

• For further information on the role and how to apply, please click here.
• The deadline to receive your application is 26 July 2024.
• The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples. 
•        Read our Recruitment Privacy Statement

Friday, July 19, 2024 Category: Jobs

Antimikrobna fotodinamička terapija kao dodatak standardnom liječenju bolesti desni oko prirodnih zubi ili dentalnih implantata Ključne poruke Nije sigurno ima li dodatak antimikrobne fotodinamičke terapije (aPDT) uz standardno liječenje ikakvih značajnih koristi za odrasle osobe s bolesti desni u usporedbi samo s uobičajenim liječenjem. Uvod Simptomi bolesti desni (parodontne bolesti) uključuju krvarenje desni, oticanje desni i loš zadah. Infekcija može oštetiti meka tkiva oko zubi, a u nekim slučajevima ljudi mogu izgubiti zube. Mnogi ljudi s dentalnim implantatom (umjetnim zubom koji je...

Thursday, July 11, 2024

Thursday, July 11, 2024

Trifokalne u usporedbi s intraokularnim lećama produženog fokusa kod ljudi koji su operirali kataraktu Koji je cilj ovog sustavnog pregleda? Ovaj Cochraneov sustavni pregled imao je za cilj procijeniti učinke umjetnih leća ugrađenih u oko nakon uklanjanja katarakte. Konkretno, htjeli smo usporediti rezultate ugradnje trifokalnih u usporedbi s intraokularnim lećama s produženim fokusom (engl. extended depth of focus, EFOD). Ključne poruke Ljudi kojima su ugrađene trifokalne ili EFOD (TECNIS Symfony) leće nakon uklanjanja katarakte mogu imati slične razine vida na daljinu. Ljudi s trifokalnim...

Cochrane's strength lies in its collaborative, global community. Cochrane Geographic Groups represent Cochrane in their host countries, advocating for the use of Cochrane evidence in health policy and practice, and supporting Cochrane's members and supporters locally. Here, we spotlight the impactful work of Cochrane Hong Kong, dedicated to increasing the use of best evidence to inform healthcare decision-making across China and neighbouring regions.

Cochrane Hong Kong, officially established in 2019, is situated at The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong. As part of the Cochrane China Network, Cochrane Hong Kong is one of eight affiliate groups across China. Today with over 800 members and supporters, they aim to expand the reach and impact of Cochrane evidence on healthcare practice and build capacity for high-quality evidence production.

Since 2022, Cochrane Hong Kong has led Cochrane Nursing, promoting nursing participation in evidence-based healthcare and actively disseminating Cochrane evidence to diverse nursing audiences. This ensures that nurses are aware of relevant Cochrane reviews that can inform their practice. They run the @CochraneNursing X account to share new evidence, supporting members in their engagement with Cochrane and enhancing the dissemination of evidence in nursing both in the broader Asian region and globally.

The group's translation efforts significantly impact healthcare practices and policies in Hong Kong and across Asia, ensuring that medical professionals and the general population have access to high-quality, evidence-based information. In collaboration with the Cochrane China Network and Cochrane Taiwan, they translate plain language summaries of Cochrane reviews into both simplified and traditional Chinese. Currently, there are 2327 plain language summaries in traditional Chinese and  3842 plain language summaries in simplified Chinese for anyone to search and read, making vital health information more accessible.

In 2022, Cochrane Hong Kong hosted the Knowledge Translation Awards, encouraging global university students to engage in knowledge translation and evidence dissemination. The event concluded with a virtual presentation ceremony to honour the awardees for their innovative contributions to advancing knowledge translation and evidence-based practice. "Cochrane Hong Kong's dedication to translating and disseminating evidence is making a significant impact on healthcare practices in China and beyond," says Professor Wai-tong Chien, Co-Director of Cochrane Hong Kong.

Cochrane Hong Kong offers comprehensive training in systematic reviews and evidence production, empowering health professionals and postgraduate students to conduct high-quality reviews. Their workshops during the 1st Cochrane Hong Kong Symposium and the 7th Pan-Pacific Nursing Conference attracted over 300 delegates. Collaborations with other Cochrane groups and external organisations significantly enhance their impact. In January 2023, they co-organised the 2nd Cochrane China Network Symposium, bringing together global healthcare researchers and experts. They also partnered with Southern Medical University for the 2023 Global Health South Forum and The First Pearl River Implementation Science Symposium (PRISIS).

Cochrane Hong Kong collaborates with the Hospital Authority Hong Kong, which governs all public hospitals in the region. They offer workshops and training on systematic reviews and evidence production. Currently, they are conducting a clinical trial to evaluate an evidence-based detection method for ensuring the correct placement of nasogastric tubes across public hospitals. This partnership aims to enhance evidence-based healthcare decisions, improve clinical practices, and establish or revise standards, guidelines, and policies to ensure the highest quality of care for patients.

Looking ahead, Cochrane Hong Kong will continue producing, translating, and disseminating Cochrane evidence. They will collaborate with healthcare institutions and Cochrane organisations to provide more workshops on evidence-based practice. "Cochrane Hong Kong's future projects will continue to build on our strong foundation, advancing evidence-informed decision-making and improving healthcare outcomes across Asia," notes Professor Janita Chau, Co-Director of Cochrane Hong Kong and Co-Chair of Cochrane Nursing. "We are particularly excited about our upcoming training workshops and fellowship programmes, which will help create the next generation of leaders in evidence-based healthcare."

Cochrane Hong Kong invites individuals and organisations in Asia that are eager to impact healthcare to collaborate and offer their support. If you are interested in contributing to their mission, please reach out at cochranehk@cuhk.edu.hk. There are numerous opportunities to engage and contribute to evidence-based healthcare!

• Visit the Cochrane Hong Kong website
• Visit the Cochrane Nursing Field website
• Search and view Cochrane evidence in simplified Chinese
• Search and view Cochrane evidence in traditional Chinese
• Find a Cochrane Geographic Group in your country

Friday, July 19, 2024

Global leaders in evidence-based healthcare - JBI, Cochrane, Campbell Collaboration, AHRU at the University of Oxford, and Institute of Development Studies (IDS) - have joined forces to launch the World Evidence-Based Healthcare (EBHC) Day 2024 campaign: "Health and Beyond: From Evidence to Action."

The World EBHC Day 2024 campaign seeks to galvanise the global evidence community in addressing the interconnected crises facing humanity. These simultaneous and interconnected crises, or ‘polycrisis’, threaten the achievement of the United Nations Sustainable Development Goals and the well-being of people worldwide.

In the face of escalating social, economic, and ecological challenges, the 2024 campaign underscores the need for greater intersectoral action and collaboration to build resilient evidence support systems.

“In a time of ongoing crises, World EBHC Day 2024 presents an important opportunity to bring together the global evidence community to find solutions collaboratively. Cochrane is pleased to be a partner and aims to ensure that momentum from the campaign continues, as there is much to be done to build a healthier world for future generations,” said Catherine Spencer, Cochrane Chief Executive Officer. 

The World EBHC Day 2024 campaign calls on organisations and individuals to share their experiences, innovations, and lessons learned in using evidence-based approaches to drive meaningful change. By facilitating dialogue and knowledge-sharing across sectors, World EBHC Day 2024 serves as a global platform to share and access collective knowledge and wisdom for health and beyond, moving from evidence to action, while highlighting that interdisciplinary collaboration and innovation is pivotal to transformative change.

 Cochrane’s Editor-in-Chief, Dr Karla Soares-Weiser, also shared her enthusiasm for the campaign: “World Evidence-Based Healthcare Day 2024 demonstrates how it is essential to co-create solutions for the complex global challenges of our time. This aligns with the work we have been doing at Cochrane to develop our new Scientific Strategy, which will be published later this year.” 

JBI, Cochrane, The Campbell Collaboration, AHRU at University of Oxford and IDS call on the global evidence community to share their experiences, challenges, innovations, lessons learned, and promising failures in using evidence-based approaches to take action for health and beyond. 

• For more information on the World Evidence-Based Healthcare Day 2024 campaign and how to participate please visit https://worldebhcday.org 
• If you are interested in writing a blog or recording a vlog for World EBHC Day 2024, please get in touch with msalman@cochrane.org

About World EBHC Day: World Evidence-Based Healthcare (EBHC) Day is held on 20 October each year. It is a global initiative that was founded by JBI that raises awareness of the need for better evidence to inform healthcare policy, practice and decision making in order to improve health outcomes globally. It is an opportunity to participate in debate about global trends and challenges, but also to celebrate the impact of individuals and organisations worldwide, recognising the work of dedicated researchers, policymakers and health professionals in improving health outcomes.  For more information, please visit www.worldebhcday.org

Wednesday, July 17, 2024